A targeted therapy for triple negative breast cancer may lie existing drugs

Researchers identified two proteins — mutant tumor protein 53 (mtp53) and poly-ADP-Polymerase (PARP) — that are present and interacting with DNA during the replication process in patients with triple negative breast cancer. Suppressing these proteins through a combination of existing PARP-inhibiting therapies could be an effective way to interrupt the development of triple negative breast…

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Openly acknowledging social inequalities

Members of disadvantaged social groups who engage in contact with members of privileged groups are less likely to support social change toward equality, a multinational study by social psychologists at the University of Zurich shows. To reduce this effect, it is important to actively address and acknowledge inequalities in intergroup contacts. Are members of advantaged…

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Infectious disease experts warn of outbreak risks in US border detention centers

BALTIMORE, MD., Jan 29 – Over the past year, at least seven children have died from diseases including influenza while being detained by the U.S. Department of Homeland Security’s Customs and Border Protection (CBP) agency. Infectious disease experts at the University of Maryland School of Medicine (UMSOM) called for protections like influenza vaccinations to prevent…

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UCLA researchers find chronic inflammation contributes to cancer metastasis

FINDINGS The study reveals a detailed epigenetic mechanism for how interleukin-1-beta, a common cytokine that helps fight infections during inflammation, plays a critical role in cancer metastasis. The researchers found that chronic exposure to interleukin-1-beta can promote lung cancer metastasis through inheritable changes of gene expression without altering DNA sequence. Because of these gene alterations,…

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Researchers seek to solve decades-long Baja California peninsula mystery

There’s something weird going on inside the plants and animals that call the Baja California peninsula home. On the surface, everything looks as expected, but close genetic inspection of many individuals reveals a genomically distinct split between the northern and southern populations of dozens of species. A cross-disciplinary team of researchers from the University of…

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