Primary hyperoxaluria type 1 (PH1) is an autosomal recessive inherited disorder that begins in childhood and adolescence. Various defects in the enzyme alanine-glyoxylate aminotransferase cause an overproduction of oxalate in the liver, which is excreted in the urine (hyperoxaluria). It leads to the formation of recurrent kidney stones, renal calcification (nephrocalcinosis) and kidney injury, even…
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ANCA-associated vasculitis (AAV) is a systemic disease involving the formation of special autoantibodies (so-called anti-neutrophil cytoplasmic antibodies/ANCA) and vascular inflammation. There are several diseases associated with involvement of the kidneys, lungs, upper respiratory tract, heart, skin and the nervous system; potentially life-threatening courses of disease are also possible. Immunosuppressive therapy is provided, which can lead…
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Systemic lupus erythematosus (SLE) is a chronic, inflammatory, autoimmune disease, in which damage is caused to multiple organs and tissues by the formation and deposition of immune complexes (antigen-antibody complexes). The kidneys are also affected in about half of the patients when immune complexes accumulate in the glomeruli, resulting in a glomerulonephritis called lupus nephritis…
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Here’s what you need to know: ImageThe first night the restaurant Bin707 was opened in Grand Junction, Colo., on Monday.Credit…Benjamin Rasmussen for The New York Times Some parts of the United States face financial ruin but few infections. In Corpus Christi, the oil and gas and vacation town on the southeastern coast of Texas, it…
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When the country was largely under lockdown, at least the rules were mostly clear. Essential workers ventured out; everyone else sheltered in. Bars and restaurants were closed except for dining out; hair salons and spas were shuttered. Outings were limited to the supermarket or the drugstore. Now states are lifting restrictions, but detailed guidance about…
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In March, Amy Carrier asked one of the two women who provided home care for her mother to stop coming to work. Her mother, 74, has Alzheimer’s disease and lives with her in Corvallis, Ore. To protect her from the coronavirus, “it was clear that I needed to lock down my house,” said Ms. Carrier,…
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As a Fire Island veteran, Jory Stiefel had his summer weekend ritual down to a T. He would leave work on Thursday, hop on the 3 p.m. train from Penn Station to catch the 5 p.m. Sayville ferry and arrive at Fire Island Pines, the hedonistic gay resort off the south shore of Long Island,…
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The Look 2020 A photographer and a writer separately explore black boyhood and the season. Photographs by Andre D. Wagner Text by Kiese Laymon ImageCredit…Andre D. Wagner Black boys from Mississippi know the Black boys from New York. When we were young, their parents sent them down south one summer. We were as afraid of…
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So you’re thinking about creating a neighborhood association. Shared crises have frequently galvanized community action, in formal and informal ways, and perhaps you’d like to corral that energy into organizing within your own area. These days, in the midst of the coronavirus pandemic, mutual aid networks have been incubated on Slack and ad hoc associations…
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For the last week, ever since the killing of George Floyd galvanized the world to confront not just the history of police brutality against black people but our own complicity in allowing it to happen, the social media feeds of fashion brands and influencers have filled up with black squares and statements of solidarity. And…
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