Zooming in on breast cancer reveals how mutations shape the tumour landscape

Scientists have created one of the most detailed maps of breast cancer ever achieved, revealing how genetic changes shape the physical tumour landscape, according to research funded by Cancer Research UK and published in Nature Cancer today (Monday). An international team of scientists*, brought together by an ambitious £20 million Grand Challenge award from Cancer…

Details

The Lancet Psychiatry: Life-course-persistent antisocial behaviour may be associated with differences in brain structure

MRI brain scans suggest there are characteristic differences in brain structure of individuals who exhibit life-course-persistent antisocial behaviour. Individuals who exhibit life-course-persistent antisocial behaviour – for example, stealing, aggression and violence, bullying, lying, or repeated failure to take care of work or school responsibilities – may have thinner cortex and smaller surface area in regions…

Details

Intratumoral heterogeneity may be responsible for chemotherapy resistance in patients with small cell lung cancer

HOUSTON – Small cell lung cancer (SCLC) accounts for 14% of all lung cancers and is often rapidly resistant to chemotherapy, resulting in poor clinical outcomes. Treatment has changed little for decades, but a study at The University of Texas MD Anderson Cancer Center found that chemotherapy results in increased heterogeneity within the tumor, leading…

Details

Combination drug therapy for childhood brain tumors shows promise in laboratory models

In experiments with human cells and mice, researchers at the Johns Hopkins Kimmel Cancer Center report evidence that combining the experimental cancer medication TAK228 (also called sapanisertib) with an existing anti-cancer drug called trametinib may be more effective than either drug alone in decreasing the growth of pediatric low-grade gliomas. These cancers are the most…

Details