T’s Most Gripping Long Reads From 2019

ImageRachel Weisz, photographed in New York City on May 10, 2019. Sabina jumpsuit, $495, shop‑sabina​.com. Weisz’s own necklace.Credit…Photo by Craig McDean. Styled by Marie Chaix “Rachel Weisz Is Performing for Herself” by Susan Dominus In a profile as beguiling as the actress herself, who was one of T’s four Greats honorees this year, Dominus subverts…

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Targeting cholesterol metabolism in macrophages to eliminate viral infection

Recent evidence suggests a link between cholesterol metabolism and innate immunity. Upon viral infection, macrophages show reduced cholesterol synthesis accompanied by enhanced expression of antiviral genes, including type I interferon (IFN-I). IFN-I can induce 25-hydroxycholesterol (25-HC) accumulation, which blocks viral entry. However, it has been unclear whether other cholesterol-associated metabolic products or enzymes regulate innate…

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