Immediate dialysis no better than wait-until-necessary approach, researchers find

In the largest international study of its kind, researchers at the University of Alberta and Toronto’s St. Michael’s Hospital found that an accelerated renal-replacement therapy strategy did not reduce mortality after three months, compared to a standard strategy for critically ill patients with acute kidney injury. The Standard vs. Accelerated Initiation of Renal Replacement Therapy…

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Patients with substance use disorder discriminated against by post-acute care facilities

Boston – A new study shows that 29 percent of private post-acute care facilities in Massachusetts explicitly discriminated against hospitalized individuals with opioid use disorder, rejecting their referral for admission. Led by researchers at Boston Medical Center’s (BMC’s) Grayken Center for Addiction, the study showed that 15 percent of the rejections among patients with substance…

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Combating drug resistance in age-related macular degeneration

An international team of researchers led by Baylor College of Medicine and Houston Methodist has discovered a strategy that can potentially address a major challenge to the current treatment for choroidal neovascularization (CNV), an aggressive form of age-related macular degeneration, the leading cause of irreversible blindness in the elderly. Anti-vascular endothelial growth factor (anti-VEGF)…

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Cancer cells in inhospitable brain fluids hijack iron to survive

In order to survive within the remote and harsh anatomical microenvironments of the central nervous system, the disseminated cancer cells that cause rare yet deadly leptomeningeal metastases (LM) hijack crucial iron micronutrients from native macrophages, researchers report. The work highlights the remarkable plasticity of tumor cells and reveals potential new avenues for treating these particularly…

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Recently discovered CRISPR enzyme from huge bacteriophages expands genome editing toolbox

A recently discovered hypercompact CRISPR enzyme found only in huge bacteriophages, and known as CRISPR-CasΦ, is functional, a new study by Patrick Pausch, Jennifer Doudna and colleagues reports, and it provides a powerful new tool in the CRISPR genome editing toolbox, including because it can target a wider range of genetic sequences compared to Cas9…

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Aging-associated inflammation may worsen COVID-19 outcomes in older individuals

The increased severity and mortality of SARS-CoV-2 infections in older individuals may be related to inflammageing – an age-associated phenomenon of increased general inflammation. In this Perspective, Arne Akbar and Derek Gilroy discuss this possibility as well as strategies to mitigate related effects. Inflammageing is thought to be caused, at least partially, by deterioration of…

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