Novel strategy hits ‘reset button’ for disease-causing genetic duplications

WORCESTER — Scientists at UMass Medical School have developed a strategy for editing and repairing a particular type of genetic mutation associated with microduplications using CRISPR/Cas9 and a seldom-used DNA repair pathway. Described in Nature, this approach to programmable gene editing overcomes prior inefficiencies in gene correction. “It’s like hitting the reset button,” said Scot…

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