Interleukin-12 electroporation may sensitize ‘cold’ melanomas to immunotherapies

Bottom Line: Combining intratumoral electroporation of interleukin-12 (IL-12) DNA (tavokinogene telseplasmid, or TAVO) with the immune checkpoint inhibitor pembrolizumab (Keytruda) led to clinical responses in patients with immunologically quiescent advanced melanoma, according to results from a phase II trial. Journal in Which the Study was Published: Clinical Cancer Research, a journal of the American Association…

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A Quarantine Activity for the Wine Lover

I’ve sabered open a bottle of Champagne. But disgorging one? Yes, try this at home. Just follow the step-by-step that comes with Família Geisse’s Cave Amadeu Rústico Nature from southern Brazil. In sparkling wine parlance, disgorging refers to extracting the sediment, or lees, that accumulate as the wine develops. Traditionally it’s done by gradually turning…

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Top U.K. Scientist Resigns Over Coronavirus Distancing Violation: Live Coverage

Here’s what you need to know: Caught violating his own social distancing advice, a top British scientist quits a government panel. Neil Ferguson, the epidemiologist whose frightening projections of coronavirus deaths precipitated the lockdown in Britain, resigned from the government’s scientific advisory group on Tuesday, after admitting he breached social distancing rules by illicitly meeting…

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