NFCR-funded translational cancer research project receives Virginia Catalyst grant

ROCKVILLE, MD – A translational research project supported by the National Foundation for Cancer Research (NFCR) has been awarded $700,000 from Virginia Catalyst to advance its lead cancer drug candidate. The funding will be used for collaboration among the laboratory of Virginia Commonwealth University’s (VCU) Paul Fisher, M.Ph., Ph.D., an NFCR fellow, a team at…

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New book series aims to provide frontier reviews on anti-infective agents

The series is essential reading for general readers, healthcare professionals, researchers and academicians actively involved in research on infectious diseases and anti-infective therapeutic drugs. The first volume is a comprehensive documentation on major infectious diseases from tropical countries which pose a serious threat to global healthcare programs. These include diseases such as tuberculosis, AIDS, leishmaniasis…

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Moms’ obesity in pregnancy is linked to lag in sons’ development and IQ

December 23, 2019 — A mother’s obesity in pregnancy can affect her child’s development years down the road, according to researchers who found lagging motor skills in preschoolers and lower IQ in middle childhood for boys whose mothers were severely overweight while pregnant. A team of epidemiologists, nutritionists and environmental health researchers at Columbia University…

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For CRISPR, tweaking DNA fragments before inserting yields highest efficiency rates yet

CHAMPAIGN, Ill. — University of Illinois researchers achieved the highest reported rates of inserting genes into human cells with the CRISPR-Cas9 gene-editing system, a necessary step for harnessing CRISPR for clinical gene-therapy applications. By chemically tweaking the ends of the DNA to be inserted, the new technique is up to five times more efficient than…

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Nanoparticle therapeutic restores tumor suppressor, sensitizes cancer cells to treatment

In preclinical experiments, investigators restored p53 using synthetic mRNA nanoparticles, making lung and liver cancer cells susceptible to available cancer drugs The tumor suppressor gene p53, also known as the guardian of the genome, plays a critical function in preventing cancer. Because of its powerful role, it is one of the most commonly compromised…

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