Targeting cholesterol metabolism in macrophages to eliminate viral infection

Recent evidence suggests a link between cholesterol metabolism and innate immunity. Upon viral infection, macrophages show reduced cholesterol synthesis accompanied by enhanced expression of antiviral genes, including type I interferon (IFN-I). IFN-I can induce 25-hydroxycholesterol (25-HC) accumulation, which blocks viral entry. However, it has been unclear whether other cholesterol-associated metabolic products or enzymes regulate innate…

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On nitroglycerin, cardiovascular homeostasis and…bam, migraine!

London, UK: A clinical investigation recently published in the journal Cephalalgia, the official journal of the International Headache Society, suggests that migraine patients may exhibit a systemic pathophysiological alteration. The study, entitled “Abnormal cardiovascular response to nitroglycerin in migraine”, was conducted by Dr. Willebrordus PJ van Oosterhout, from Leiden University Medical Centre, Department of Neurology,…

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