The drug maker Novartis concealed manipulated data from the Food and Drug Administration while applying for approval of an extremely expensive gene therapy treatment and then delayed reporting the issue, the agency said on Tuesday. Officials said the inaccurate data, which involved testing in mice of two different strengths of the treatment, did not affect…
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Osteoarthritis has been linked to an increased risk for cardiovascular disease, and a new study suggests that a large part of the risk comes from the use of nonsteroidal anti-inflammatory medicines, or NSAIDs. Such drugs include ibuprofen (Advil or Motrin) and naproxen (Aleve), as well as a variety of prescription NSAIDs. Researchers used Canadian health…
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It is played or performed at funerals and memorials large and small, and pushes people to tears in nearly any setting, from bars to supermarket aisles. Singalongs, often pressed through sobs, are unavoidable. “Eternal love,” the most well-known part of the lyrics say, in Spanish. “Unforgettable.” For millions of Mexican Americans, Mexicans, and anyone familiar…
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A striking portrait of Beyoncé, shot by the rising photographer Tyler Mitchell for Vogue’s all-important September issue last year, is on its way to the Smithsonian’s National Portrait Gallery in Washington. Mr. Mitchell, who is the first African-American photographer and one of the youngest to shoot a cover for Vogue, announced the news online on…
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Image Barneys on Madison Avenue, in 2014.CreditAndrew Renneisen/The New York Times It has been striking, over the last few weeks, to watch the almost gleeful flow of reports and speculation about the maybe-probably-now-confirmed bankruptcy of Barneys New York, the fabled department store. Starting in mid-July, when Reuters broke the news that a rent hike at…
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Courtesy It’s hip to be square this season, because every designer is cashing in on this shape of shoe. We’ve seen versions of this ’90s style over the years, but the newest versions are somehow… square-ier? Leading the pack is Bottega Veneta under the new creative vision of Daniel Lee. His first collection of accessories…
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Image Kevin Fallon opened Fantasy Explosion to sell decades-old T-shirts from niche corners of the city. CreditKevin Hagen for The New York Times Recently, in the basement of my mom’s house upstate, I discovered two boxes full of clothes that somehow got diverted from me back in 1997. They were full of gems — old merch…
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“Tinder’s definitely not a game,” said Elie Seidman, the company’s chief executive, in a recent interview. “At the core, it’s about human connection.” If you squint, though, the app doesn’t look so different from the countless mobile games on the market. Tinder has a clear objective and explicit rules. At any time of day, there…
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