NIH-sponsored ACTIV-3 clinical trial closes enrollment into two sub-studies

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The ACTIV-3 clinical trial, which is evaluating the safety and efficacy of investigational therapeutics for COVID-19 in hospitalized patients, has closed enrollment in two sub-studies: one examining the investigational monoclonal antibody therapy VIR-7831, and another evaluating the investigational combination monoclonal antibody therapy containing BRII-196 and BRII-198. The sub-studies were halted by the trial sponsor, the…

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The social support for mothers of patients with eating disorders

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Background: Although caregivers of patients with eating disorders usually experience a heavy caregiving burden, the effects of social support on caregivers of patients with eating disorders are unknown. This study aimed to investigate how social support for mothers who are caregivers of patients with an eating disorder improves the mothers’ mental status and, consequently, the…

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BCAS3-C16orf70 complex is a new actor on the mammalian autophagic machinery

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Autophagy is an intracellular degradation process of cytosolic materials and damaged organelles. Researchers at Ubiquitin Project of TMIMS have been studying the molecular mechanism of mitophagy, the selective autophagy process to eliminate damaged mitochondria. PINK1 (a serine/threonine kinase) and Parkin (a ubiquitin ligating enzyme: E3) work together to ubiquitylate the outer membrane proteins of damaged…

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Molecular mechanisms identified in chronic skin inflammation

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Frequently occurring chronic skin inflammation like in atopic dermatitis (AD or neurodermatitis) and psoriasis have different causes such as genetic predisposition, stress or allergens. These frequently occurring skin diseases are mostly attributed by biomedical scientists to a disturbed immune system, although the noticeable thickening and flaking of the epidermis, which is the outermost layer of…

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The future of contactless care: robotic systems gain patient approval

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WHO: Giovanni Traverso, MB, BChir, PhD, Associate Physician, Division of Gastroenterology, Brigham and Women’s Hospital; corresponding author of a new article published in JAMA Network Open. Peter Chai, MD, MMS, Assistant Professor, Department of Emergency Medicine, Brigham and Women’s Hospital; first author. WHAT: In the age of COVID-19, mobile robotic telehealth systems could help clinicians…

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