Tumor microenvironment analyzed to increase effectiveness of preclinical trials

IMAGE: Analysis of self-organization of MSCs, Hela, and PBMCs after 72 h of co-culture. Arrows indicate fused cells. (A) Alexa Fluor 647 (MSCs), (B) PE (HeLa), (C) FITC (PBMCs), (D, D1,… view more  Credit: Kazan Federal University It was shown that co-culturing HeLa adenocarcinoma cells, peripheral blood mononuclear cells, and mesenchymal stromal cells results in changes…

High throughput method to produce and screen engineered antimicrobial lanthipeptides

IMAGE: Alginate microbeads containing colonies of target cells (green) and producer cells (red). Where the producer cells indeed secrete active lantibiotics, the target cells have disappeared. view more  Credit: Steven Schmitt ETH Zürich Nature has provided us with lots of antimicrobials. However, given the rapid increase of antimicrobial resistance, there is a need for the development…

Can delayed/extended-release methylphenidate allow for once daily evening dosing in ADHD?

IMAGE: Journal of Child and Adolescent Psychopharmacology is dedicated to child and adolescent psychiatry and behavioral pediatrics, covering clinical and biological aspects of child and adolescent psychopharmacology and developmental neurobiology…. view more  Credit: Mary Ann Liebert, Inc., publishers New Rochelle, NY, April 2, 2019–A new three-part study showed that a delayed-release, extended-release form of methylphenidate could…

Vietnam’s Empty Forests

Despite long and tragic wars with the Japanese, the French, the Chinese and the United States during the last century, Vietnam is a treasure house. It is one of the world’s hot spots of biological diversity, according to the science research. There are 30 national parks in a country a bit larger than New Mexico,…

Front Burner: The French Cheese Biography

In his informative book, “Fromages,” Dominique Bouchait explains French cheeses, dividing them into “families,” according to how they’re made, like cooked and uncooked or blue-veined. But what he says about the French varieties applies to cheeses from anywhere. Though Mr. Bouchait — a master cheesemaker based in southwest France — focuses on the 45 French…