Savoring Lisbon’s Local Tastes on a Budget

Lisbon may be one of Europe’s more affordable capitals, but if you’re in search of a spectacular meal, it’s not difficult to drop 120 euros (about $135) for a three-course dinner (without wine) at restaurants like the Michelin-starred Belcanto. Fortunately, budget travelers can turn to tascas: small, unpretentious restaurants that, back in the early part…

You Love to ‘Hate to See It’

I saw it from a friend, who saw it from teen students who forgot their permission slips. Other people saw it during the 2019 N.B.A. playoffs, or while reading about wives in The New Yorker. If you’re active on social media, there’s a good chance you’ve already seen it; even if you aren’t, it’s coming…

Immunology — not just supporting actors

Non-classical monocytes were long thought to play a purely surveillance role in the immune system. With the aid of a novel marker (PD-L1), Ludwig-Maximilians-Universitaet (LMU) in Munich researchers have now shown that they are directly involved in the regulation of immune response. Monocytes comprise a functionally specific group of white blood cells and are known…

Structural development of the brain

IMAGE: When Ncad expression and adhesiveness were reduced in R7, which is usually situated at the central core region of the column, R7 terminals were redirected to the peripheral region of… view more  Credit: Kanazawa University The human brain consists of neurons arranged into microscopic columns. The cortex, which is the seat of most cerebral functions…

Mystery of immunosuppressive drug’s biosynthesis finally unlocked

Mycophenolic acid (MPA), discovered in 1893, was the first natural antibiotic to be isolated and crystallized in human history. Today, this fungal metabolite has been developed into multiple first-line immunosuppressive drugs to control immunologic rejection during organ transplantation and treat various autoimmune diseases. However, the biogenesis of such an old and important molecule was an…