Cold-induced urticarial rash — researchers discover new hereditary disease

Skin rash combined with head and joint pain: these are the symptoms which patients with familial (hereditary) cold urticaria develop when exposed to temperatures below 15 °C. Researchers from Charité – Universitätsmedizin Berlin have discovered a new, previously unknown form of this inflammatory skin disorder. In addition to explaining why conventional treatments are ineffective in…

ISSCR 2020 Virtual Meeting registration open

Skokie, IL – The International Society for Stem Cell Research has transformed its annual scientific meeting into a virtual experience, bringing the global stem cell community together to share knowledge, collaborate, and network. Registration is now open. The ISSCR 2020 Virtual Meeting, cosponsored by the Harvard Stem Cell Institute (HSCI), will deliver a comprehensive scientific…

Herpes virus decoded

Until now, scientists had assumed that there are about 80 so-called open reading frames (ORFs) in the genome of herpes simplex virus 1 (HSV-1). These are the locations in the genome where the information in the DNA is read and translated into proteins. It is now clear that there are a lot more – namely…

MD Anderson and Ipsen advance new therapy with potential benefit for underserved patients with lung and ovarian cancers

HOUSTON — In a first-time disclosure of IPN60090, a small-molecule inhibitor of the metabolic enzyme glutaminase (GLS1), researchers from The University of Texas MD Anderson Cancer Center’s Therapeutics Discovery division and Ipsen Biopharmaceuticals reported the preclinical discovery and early-stage clinical development of this novel drug. IPN60090, now under investigation in a Phase I trial, may…