IMAGE: Structures of the catalytic domains of USP28 and USP25: USP28 is a constitutively active dimer and can bind and process ubiquitin (orange) at any time. In contrast, USP25 is a… view more Credit: Picture: Rudolf Virchow Center of experimental biomedicine / University of Wuerzburg The permanent interplay of protein production and degradation is a major…
IMAGE: Radiolabeled protein lights up tumor implanted in the arm of a mouse under a PET scan. The researchers hope to use scans like this one to to calculate in real… view more Credit: Sridhar Nimmagadda Experimenting with mice, Johns Hopkins researchers report they have successfully used positron emission tomography (PET) scans to calculate in real…
Mike Greco, who was known to connoisseurs of Italian cuisine as “the Salami King” and “the Mayor of Arthur Avenue,” and whose salumeria has catered to old neighbors, visiting politicians and insatiable Bronx expatriates for more than six decades, died on March 22 in White Plains. He was 89. His death was confirmed by his…
The announcement by Chicago prosecutors on Tuesday that they were dropping all charges against the “Empire” actor Jussie Smollett was the latest turn in a strange and twisting case. And it enraged the city’s own mayor and police superintendent. Joe Magats, the prosecutor, said the charges were dropped after Mr. Smollett, accused of staging a…
Purdue Pharma, the maker of OxyContin, and its owners, the Sackler family, agreed to pay $270 million to avoid going to a state court trial over the company’s role in the opioid addiction epidemic that has killed more than 200,000 Americans over the past two decades. The payment, negotiated to settle a case brought by…
The Affordable Care Act was already in peril after a federal judge in Texas invalidated the entire law late last year. But the stakes ramped up again this week, when President Trump’s Justice Department announced it had changed its position and agreed with the judge that the entire law, not just three pieces of it,…
WASHINGTON — The Trump administration broadened its attack on the Affordable Care Act on Monday, telling a federal appeals court that it now believed the entire law should be invalidated. The administration had previously said that the law’s protections for people with pre-existing conditions should be struck down, but that the rest of the law,…
Maybe it’s Instagram, but sometime in the past three or four years it seems like everyone’s started wearing thong bikinis. Wedgies may be in, but some of us want out. So we’ve got you covered—literally. Shop 13 modest swimsuits (with full coverage bottoms!) that are still wildly cute, ahead. The Alison One-Piece Courtesy Solid and…
A Long To-Do List The night you were discharged from the clinic where we had been both patient and prisoner, you tried to throw yourself into blinding headlights. Days later, I visited you in a new white room. You showed me a list of things you wanted to do. It was long, and I was…
Image The staff of The Face, including Stuart Brumfitt, the editor (in the yellow pullover), and Jason Gonsalves, the brand director (in the yellow beanie). CreditTom Jamieson for The New York Times In the January 1999 issue of The Face, a British style magazine, there was an anonymous letter from a gay closeted 17-year-old schoolboy.…