Mystery of immunosuppressive drug’s biosynthesis finally unlocked
Mycophenolic acid (MPA), discovered in 1893, was the first natural antibiotic to be isolated and crystallized in human history. Today, this fungal metabolite has been developed into multiple first-line immunosuppressive drugs to control immunologic rejection during organ transplantation and treat various autoimmune diseases. However, the biogenesis of such an old and important molecule was an…