Why cells need acidic lysosomes

Just like the body contains lungs, liver, and lymph nodes, so does each of the body’s cells contain tiny specialized organs. Perhaps most peculiar among them are lysosomes–bubble-like sacks that act as part recycling bin, part stomach. Among other things, a lysosome devours cellular debris–and, like a stomach, it needs to be acidic to do…

Liver fibrosis ‘off switch’ discovered in mice

Chronic alcohol abuse and hepatitis can injure the liver, often leading to a buildup of collagen and scar tissue. Understanding this process, known as liver fibrosis, could help researchers develop new ways to prevent or treat conditions such as alcoholic liver disease, non-alcoholic steatohepatitis (NASH) and nonalcoholic flatty liver disease (NAFLD). In a study published…

A Party Spot Opens Near Chinatown

Omar’s La Boîte Lower East Side Omar Hernandez, the restaurateur and night life spirit animal, has set his sights on the Lower East Side. After making a name for himself in Miami, Mr. Hernandez arrived in Greenwich Village in 2013 and opened Omar’s La Ranita, a private supper club that had a brief but storied…

How to Throw a Dinner Party Like a Gallerist

“It was love at first sight,” said the writer Sarah Thornton, of meeting the gallerist Jessica Silverman at an art fair in London nine years ago. “Her stand was so confidently curated.” Now happily partnered, they live in an eighth-floor apartment in San Francisco’s historic Nob Hill neighborhood — facing Grace Cathedral’s stained-glass rosette windows…