Analysis of immune responses in COVID-19 patients identifies defining features of severe disease

An analysis of immune responses in 42 COVID-19 patients, both infected and recovered, identified immune signatures that distinguish severe COVID-19 cases. Notably, the analysis features insights not only into adaptive immune cell responses, but also those of innate immune cells responding to the virus. The findings will inform development of COVID-19 therapeutics. As the global…

Detailed study of immune responses in COVID-19 patients reveals distinct ‘immunotypes’

Expanding on observations made in smaller patient cohorts, researchers studying immune responses of 125 hospitalized COVID-19 patients identified distinct immune profiles — “Immunotypes” — and showed how these signatures correlated with disease severity. “By localizing patients on an immune topology map,” Divij Mathew and colleagues say, “we can begin to infer which types of therapeutic…