In order to survive within the remote and harsh anatomical microenvironments of the central nervous system, the disseminated cancer cells that cause rare yet deadly leptomeningeal metastases (LM) hijack crucial iron micronutrients from native macrophages, researchers report. The work highlights the remarkable plasticity of tumor cells and reveals potential new avenues for treating these particularly…
A recently discovered hypercompact CRISPR enzyme found only in huge bacteriophages, and known as CRISPR-CasΦ, is functional, a new study by Patrick Pausch, Jennifer Doudna and colleagues reports, and it provides a powerful new tool in the CRISPR genome editing toolbox, including because it can target a wider range of genetic sequences compared to Cas9…
The increased severity and mortality of SARS-CoV-2 infections in older individuals may be related to inflammageing – an age-associated phenomenon of increased general inflammation. In this Perspective, Arne Akbar and Derek Gilroy discuss this possibility as well as strategies to mitigate related effects. Inflammageing is thought to be caused, at least partially, by deterioration of…
Welcome. How are you? Wednesdays were a bear even before the pandemic came to town and made most days feel like Wednesdays. Now Wednesdays are like Wednesdays squared, like Nebraska on a cross-country drive, 456 miles from Omaha in the East all the way to the Wyoming line. They’re a long way from a weekend…
Wading into the contentious debate over reopening schools, an influential committee of scientists and educators on Wednesday recommended that, wherever possible, younger children and those with special needs should attend school in person. Their report — issued by the prestigious National Academies of Science, Engineering and Medicine, which advises the nation on issues related to…
One of the joys of working from home is being able to make myself something for lunch that no one else in my family even remotely likes. No matter if it’s stuffed with garlicky bread crumbs, spiced grains, ground meat, canned fish, beans or cheese, there’s something about the soft texture of a baked tomato…
We have seen the future of European fashion, and it is California. Peering out from behind the curtain of a long lockdown, designers in Paris and Milan seemed unanticipatedly hopeful during the digital shows this past week. It was not so much that they were willing to forgo the inimitable theater of the fashion show…
At first glance, American paddlefish and Russian sturgeon seem about as different as two fish can be. The Russian sturgeon, whose eggs are used to make top-shelf caviar, is a carnivore that hoovers crustaceans and smaller fish off the floor of rivers, lakes and coastal areas the world over. The American paddlefish, found in only…
Good morning. The chef Brooks Headley is in the spotlight today, with his recipe for the crispy chicken-fried tofu sandwich (above) served at his Superiority Burger on the Lower East Side of Manhattan. It’s a bit of a project as most restaurant recipes tend to be, but it’s neither complicated nor difficult. If you start…
Early in the Covid-19 pandemic, researchers found preliminary evidence suggesting that people’s blood type might be an important risk factor — both for being infected by the virus and for falling dangerously ill. But over the past few months, after looking at thousands of additional patients with Covid-19, scientists are reporting a much weaker link…