LOUISVILLE, Ky. – The SARS-CoV-2 pandemic has caused tremendous upheaval, leading to more than 2.3 million deaths worldwide and 465,000 in the United States. Understanding the impact of seasonal temperature changes on transmission of the virus is an important factor in reducing the virus’s spread in the years to come. SARS-CoV-2 belongs to a large…
ROCHESTER, Minn. ? Researchers at Mayo Clinic have combined results from a functional test measuring the effect of inherited variants in the BRCA2 breast and ovarian cancer gene with clinical information from women who received genetic testing to determine the clinical importance of many BRCA2 variants of uncertain significance (VUS). The findings were published today…
Cancer biologists at Weill Cornell Medicine have been awarded a 2021 Top 10 Clinical Research Achievement Award from the Clinical Research Forum for their study last year describing a highly sensitive blood test for monitoring cancer progression and relapse. The findings, entitled “Genome-wide cell-free DNA mutational integration enables ultra-sensitive cancer monitoring,” were published June 1…
A new study published in The British Medical Journal by researchers including SFU health sciences professor Scott Lear found consuming a high number of refined grains, such as croissants and white bread, is associated with a higher risk of major cardiovascular disease, stroke and death. The Prospective Urban Rural Epidemiology (PURE) study has been examining…
Scientists have discovered the first evidence of protein folding driven by liquid-liquid phase separation, a phenomenon in which fluids form into microscopic droplets and separate inside cells — like drops of oil in water. In a study published in the journal Chemical Science, researchers at the University of Notre Dame found that elevated concentrations of…
In African Americans, the genetic risk landscape for inflammatory bowel disease (IBD) is very different from that of people with European ancestry, according to results of the first whole-genome study of IBD in African Americans. The authors say that future clinical research on IBD needs to take ancestry into account. Findings of the multi-center study,…
In a new Review, P.J. Klasse and colleagues present an extensive overview of the immunogenicity profiles of several leading SARS-CoV-2 vaccine candidates, including several developed under the auspices of the U.S. Government’s “Operation Warp Speed” program, as well as leading candidates from China and Russia. Since the paper was submitted, two of these vaccines –…
Exploratory analyses including 17,178 participants find that higher vaccine efficacy is obtained with a longer interval between the first and second standard dose (81% for 3-month interval vs 55% for up to 6-week interval). In addition, a single dose of vaccine is highly efficacious in the first 3 months (76% efficacy from 22 days after…
The battle against late-stage prostate cancer might have found a potential new strategy to combat this deadly disease. Research led by Baylor College of Medicine reveals in the Journal of Clinical Investigation that the enzyme MAPK4 concertedly activates androgen receptor (AR) and AKT, molecules at the core of two cellular signaling pathways known to promote…
Several University of Illinois Chicago faculty members have addressed the issue of how to ethically conduct research with Black populations. In their paper “Ethics of Research at the Intersection of COVID-19 and Black Lives Matter: A Call to Action,” authors Natasha Crooks, an assistant professor, Phoenix Matthews, a professor, both of the UIC College of…