Psychiatric patients at increased risk of COVID-19 hospitalization and mortality

Main points Strong evidence that patients with pre-existent mental disorders are twice as likely to die or be hospitalised after SARS-CoV-2 infection Psychotic and mood disorders are linked with COVID-19-associated mortality, as are exposure to antipsychotic and anxiolytic treatments. Patients with substance use disorders are at increased risk of hospitalisation. In the largest systematic review…

Cellular push and pull, a key to the body’s response to processes such as cancer

IMAGE: Isaac Almendros and Pere Roca-Cusachs (from left to right) leaders of the research. view more  Credit: IBEC From the vocal cords that produce our voice, to our heartbeat, our body’s cells are constantly subjected to mechanical forces that steadily change their response to these stimuli, regulating vital processes, in healthy individuals and in diseases such…

From genes to memes: Algorithm may help scientists demystify complex networks

UNIVERSITY PARK, Pa. — From biochemical reactions that produce cancers, to the latest memes virally spreading across social media, simple actions can generate complex behaviors. For researchers trying to understand these emergent behaviors, however, the complexity can tax current computational methods. Now, a team of researchers has developed a new algorithm that can serve as…

New theory suggests blood immune and clotting components could contribute to psychosis

A scientific review has found evidence that a disruption in blood clotting and the first line immune system could be contributing factors in the development of psychosis. The article, a joint collaborative effort by researchers at RCSI University of Medicine and Health Sciences, Cardiff University and the UCD Conway Institute, is published in Molecular Psychiatry.…

When mad AIOLOS drags IKAROS down: A novel pathogenic mechanism

IMAGE: The transcription factors IKAROS and AIOLOS (named after Greek mythology characters) regulate lymphocyte development. According to Greek mythology, Ikaros had wings that were made of feathers and wax; one day,… view more  Credit: Department of Pediatrics and Developmental Biology,TMDU Tokyo, Japan – Primary immunodeficiencies, such as severe combined immunodeficiency disease (SCID), occur when the immune…

First 3D simulation of rat’s complete whisker system acts as a tactile ‘camera’

Northwestern University engineers have developed the first full, three-dimensional (3D), dynamic simulation of a rat’s complete whisker system, offering rare, realistic insight into how rats obtain tactile information. Called WHISKiT, the new model incorporates 60 individual whiskers, which are each anatomically, spatially and geometrically correct. The technology could help researchers predict how whiskers activate different…