The sneaky way estrogen drives brain metastasis in non-estrogen-dependent breast cancers

IMAGE: Diana Cittelly, PhD, and colleagues show that while estrogen does not directly influence triple-negative breast cancer cells, estrogen can ‘fertilize’ brain tissue in a way that supports cancer metastasis view more  Credit: University of Colorado Cancer Center Triple-negative breast cancers are more likely than other breast cancer types to metastasize and are especially likely to…

Considerably reduced toxicant levels in heated tobacco prototype compared to cigarettes

Bristol, February 28th 2019 – New research* suggests that toxicants of notable public health interest are substantially reduced in the aerosol from our heated tobacco product (HTP) prototype, compared to smoke from a standard reference cigarette. HTPs generate a nicotine-containing aerosol with a tobacco taste through the heating of tobacco via an electrical device. The…

EMA qualification opinion on cellular therapy module of the EBMT Registry

The European Society for Blood and Marrow Transplantation (EBMT) registry has been qualified by EMA as a suitable platform for the collection of data for post-authorisation safety surveillance studies. The registry is now considered suitable to perform pharmacoepidemiological studies for regulatory purposes, concerning Chimeric Antigen Receptor (CAR) T-cell therapy used in the treatment of haematological…