SARS-CoV-2 hijacks two key metabolic pathways to rapidly replicate in host cells

When SARS-CoV-2, the virus that causes COVID-19, infects a human cell, it quickly begins to replicate by seizing the cell’s existing metabolic machinery. The infected cells churn out thousands of viral genomes and proteins while halting the production of their own resources. Researchers from Brigham and Women’s Hospital, Massachusetts General Hospital (MGH), and the Broad…

Researchers enhance Alzheimer’s disease classification through artificial intelligence

(Boston)– Warning signs for Alzheimer’s disease (AD) can begin in the brain years before the first symptoms appear. Spotting these clues may allow for lifestyle changes that could possibly delay the disease’s destruction of the brain. “Improving the diagnostic accuracy of Alzheimer’s disease is an important clinical goal. If we are able to increase the…

Enzymatic danse macabre of lung cancer

A chromatin-regulating enzyme has been shown by in-depth interdisciplinary investigations to be a key driver of a common type of lung cancer. Drugs that target the enzyme could improve treatment and survival rates for this particular cancer. “Squamous cell carcinoma represents nearly one third of all lung cancers in humans,” says KAUST structural biologist Lukasz…