ANCA-associated vasculitis: The ADVOCATE Study

ANCA-associated vasculitis (AAV) is a systemic disease involving the formation of special autoantibodies (so-called anti-neutrophil cytoplasmic antibodies/ANCA) and vascular inflammation. There are several diseases associated with involvement of the kidneys, lungs, upper respiratory tract, heart, skin and the nervous system; potentially life-threatening courses of disease are also possible. Immunosuppressive therapy is provided, which can lead…

Hope for patients with primary hyperoxaluria type 1

Primary hyperoxaluria type 1 (PH1) is an autosomal recessive inherited disorder that begins in childhood and adolescence. Various defects in the enzyme alanine-glyoxylate aminotransferase cause an overproduction of oxalate in the liver, which is excreted in the urine (hyperoxaluria). It leads to the formation of recurrent kidney stones, renal calcification (nephrocalcinosis) and kidney injury, even…

Coronavirus Global News Tracker: Live Updates

Here’s what you need to know: ImageWorkers disinfect a street in downtown Cairo last week.Credit…Fadl AbuZaid/Picture Alliance, via Getty Images The virus surges in regions where populist leaders thought they’d been spared. For months, one enduring mystery of the coronavirus was why some countries with rickety health systems and crowded slums had managed to avoid…

NMDA receptors may link psychosis and sleep deficits

Sofya Kulikova, a researcher at HSE University in Perm, is part of an international research team that has discovered potential mechanisms that explain the sleep spindle deficit in electroencephalograms (EEG) of people with schizophrenia. The article was published in the Schizophrenia Research on June 5. https://www.sciencedirect.com/science/article/abs/pii/S092099642030236X?via%3Dihub&fbclid=IwAR2VFGlKtqeYMsdtFidYS5yNpbarRGRA8Wts6TkIOCiWyDfkBot7z_yJs7w Individuals with schizophrenia are often characterized by a deficit…