New CRISPR C-to-G DNA base editor expands the landscape of precision genome editing

BOSTON – New genome-editing technologies developed by researchers in J. Keith Joung’s laboratory at the Massachusetts General Hospital (MGH) have the potential to help understand disease-associated genetic mutations that are based on C-to-G (cytosine to guanine) single base changes. The new base editors are also designed to minimize unintended (“off-target”) mutations that could potentially cause…

Scientists chart SARS-CoV-2 origin and transmission in Brazil, harboring one of fastest growing COVID-19 epidemics in the world

A team of Brazilian and European scientists has determined the transmission rates and out-of-country origins of predominant SARS-CoV-2 strains currently circulating in Brazil, which harbors one of the fastest growing COVID-19 epidemics in the world. Although the researchers show that non-pharmaceutical interventions initially reduced viral transmission, the continued increases in both cases and deaths in…

Before the A.D.A., There Was Section 504

Listen to This Article Computer-generated audio recording When the Rehabilitation Act of 1973 was passed to prohibit employment discrimination based on disability, it was supposed to protect disabled people and ensure their rights in the United States. “No otherwise qualified individual with a disability in the United States,” Section 504 of that law reads, “shall,…