Super-sensitive cancer blood test earns “Top 10” award from clinical research forum

Cancer biologists at Weill Cornell Medicine have been awarded a 2021 Top 10 Clinical Research Achievement Award from the Clinical Research Forum for their study last year describing a highly sensitive blood test for monitoring cancer progression and relapse. The findings, entitled “Genome-wide cell-free DNA mutational integration enables ultra-sensitive cancer monitoring,” were published June 1…

Good cop, bad cop

Cancer researcher Rita Fior uses zebrafish to study human cancer. Though this may seem like an unlikely match, her work shows great promise with forthcoming applications in personalised medicine. The basic principle of Fior’s approach relies on transplanting human cancer cells into dozens of zebrafish larvae. The fish then serve as “living test tubes” where…

Direct cloning method CAPTUREs novel microbial natural products

Microorganisms possess natural product biosynthetic gene clusters (BGCs) that may harbor unique bioactivities for use in drug development and agricultural applications. However, many uncharacterized microbial BGCs remain inaccessible. Researchers at University of Illinois Urbana-Champaign previously demonstrated a technique using transcription factor decoys to activate large, silent BGCs in bacteria to aid in natural product discovery.…

Mayo Clinic researchers develop test to measure effect of breast cancer gene variants

ROCHESTER, Minn. ? Researchers at Mayo Clinic have combined results from a functional test measuring the effect of inherited variants in the BRCA2 breast and ovarian cancer gene with clinical information from women who received genetic testing to determine the clinical importance of many BRCA2 variants of uncertain significance (VUS). The findings were published today…