2021

The Lancet: COVID-19 vaccination potential will not be achieved without increased production, affordable pricing, global availability, and successful rollout

Peer-reviewed / Review, Survey and Opinion piece To ensure an effective global immunisation strategy against COVID-19, vaccines need to be produced at scale, priced affordably, and allocated globally so that they are available where needed, and successfully rolled out. Review of evidence includes a comparison of 26 leading vaccines on their potential contribution to…

Medication-based starvation of cancer cells

The drug thalidomide was sold as a sedative under the trade name Contergan in the 1950s and 1960s. At the time, its side-effects triggered one of the largest pharmaceutical scandals in history: The medication was taken from the market after it became known that the use of Contergan during pregnancy had resulted in over 10,000…

Liquid biopsy for colorectal cancer could guide therapy for tumors

A new study from Washington University School of Medicine in St. Louis demonstrates that a liquid biopsy examining blood or urine can help gauge the effectiveness of therapy for colorectal cancer that has just begun to spread beyond the original tumor. Such a biopsy can detect lingering disease and could serve as a guide for…

NIH research funding to support surgeon scientists is rising

CHICAGO (February 12, 2021): Since 2010, National Institutes of Health (NIH) funding to support surgeon scientists has, remarkably, risen significantly while funding to support other non-surgeon physicians has significantly decreased. This growth has occurred despite an overall decrease in NIH funding and an increase in demand for clinical productivity. These findings are according to an…

Bacterial degradation of the MYC oncogene — a new cancer treatment strategy?

Scientists at Lund University have discovered how E. coli bacteria target and degrade the well-known oncogene MYC, which is involved in many forms of cancer. The study is now published in Nature Biotechnology. Cancer cells grow too fast, outcompete normal cells and spread to distant sites, where they cause metastases. Understanding what makes cancer cells…

Study suggests sounds influence the developing brain earlier than previously thought

FOR IMMEDIATE RELEASE Scientists have yet to answer the age-old question of whether or how sound shapes the minds of fetuses in the womb, and expectant mothers often wonder about the benefits of such activities as playing music during pregnancy. Now, in experiments in newborn mice, scientists at Johns Hopkins report that sounds appear to…

Dark-skinned teens, females prime targets of acne’s psychological fallout

A more aggressive approach to treating acne that marries the disciplines of psychology and dermatology is needed, according to two UC Riverside psychology researchers. They also assert that women and people with darker skin disproportionately suffer from acne’s psychological impacts. “Acne is pervasive, physically harmless, and painless, so we all-too-often underestimate its impacts as the…

Metabolic response behind reduced cancer cell growth

peer review/experimental study/animals/cells Researchers from Uppsala University show in a new study that inhibition of the protein EZH2 can reduce the growth of cancer cells in the blood cancer multiple myeloma. The reduction is caused by changes in the cancer cells’ metabolism. These changes can be used as markers to discriminate whether a patient would…

Researchers identify potential revolutionary new drug treatment for fatal childhood cancer

Every year around 20 Australian children die from the incurable brain tumour, Diffuse Intrinsic Pontine Glioma (DIPG). The average age of diagnosis for DIPG is just seven years. There are no effective treatments, and almost all children die from the disease, usually within one year of diagnosis. A paper published today 12 Feb 2021 in…

New synthetic peptides could attenuate atherosclerosis

Research over the last 20 years has shown that atherosclerosis is a chronic inflammatory condition of the arterial blood vessel wall. Soluble mediators such as cytokines and chemokines are pivotal players in this disease, promoting vascular inflammation. However, the development of anti-inflammatory therapeutics directed against such mediators that could prevent atherosclerosis has proven difficult, despite…