X-ray laser sight reveals drug targets

Researchers from the Moscow Institute of Physics and Technology have published a review on serial femtosecond crystallography, one of the most promising methods for analyzing the tertiary structure of proteins. This technique has rapidly evolved over the past decade, opening new prospects for the rational design of drugs targeting proteins previously inaccessible to structural analysis.…

Taking out the protein garbage becomes more difficult as neurons age

IMAGE: Aberrantly formed autophagosomes accumulate in neuron of an aged mouse. view more  Credit: Andrea Stavoe, Penn Medicine; eLife PHILADELPHIA – Cells dispose of harmful “trash” through autophagy, a normal and necessary process in which aggregated proteins and dysfunctional structures are handled. If any part of this fails, waste builds up inside cells, eventually killing them.…

The University of Bonn is the most successful participant in the Excellence Strategy competition

IMAGE: Rector Prof. Dr. Dr. h.c. Michael Hoch celebrates the excellence decision. view more  Credit: Barbara Frommann/Uni Bonn It is with boundless joy and pride that the University of Bonn has received the decision of the Excellence Commission to grant the Rheinische Friedrich-Wilhelms-Universität Bonn the status of a University of Excellence. It is one of only…

Routine blood tests could predict diabetes

IMAGE: Dr. Mary Rhee, a physician-researcher with the Atlanta VA and Emory University, discusses the use of a glucometer with VA patient Joseph Fields. view more  Random plasma glucose tests could be used to predict which patients will develop diabetes, according to a study of Veterans Affairs treatment data. Researchers from several VA systems showed that…