T’s Most Gripping Long Reads From 2019

ImageRachel Weisz, photographed in New York City on May 10, 2019. Sabina jumpsuit, $495, shop‑sabina​.com. Weisz’s own necklace.Credit…Photo by Craig McDean. Styled by Marie Chaix “Rachel Weisz Is Performing for Herself” by Susan Dominus In a profile as beguiling as the actress herself, who was one of T’s four Greats honorees this year, Dominus subverts…

Targeting cholesterol metabolism in macrophages to eliminate viral infection

Recent evidence suggests a link between cholesterol metabolism and innate immunity. Upon viral infection, macrophages show reduced cholesterol synthesis accompanied by enhanced expression of antiviral genes, including type I interferon (IFN-I). IFN-I can induce 25-hydroxycholesterol (25-HC) accumulation, which blocks viral entry. However, it has been unclear whether other cholesterol-associated metabolic products or enzymes regulate innate…