Hinge-like protein may open new doors in cystic fibrosis treatment

IMAGE: A potentiator (orange) binds to a protein ‘hotspot,’ altering the molecule’s conformation. view more  Credit: Laboratory of Membrane Biology and Biophysics at The Rockefeller University In recent decades, treatment options for people with cystic fibrosis have improved dramatically. The newest drugs, known as potentiators, target a protein called cystic fibrosis transmembrane conductance regulator, which is…

University of Pittsburgh group brings computation and experimentation closer together

IMAGE: Frames from a 10 hour long time-lapse sequence with model prediction (red line) and explant spreading (dotted line). ‘Good’ models predict not only the extent of the movement but also… view more  Credit: MechMorpho Lab/University of Pittsburgh PITTSBURGH (July 9, 2019) … A bioengineering group from the University of Pittsburgh Swanson School of Engineering is…