June 2019

Ribociclib plus hormone therapy extends survival for patients with premenopausal advanced hormone receptor-positive breast cancer

IMAGE: This is Debu Tripathy, M.D. view more  Credit: MD Anderson Cancer Center ABSTRACT LBA1008 Adding the targeted therapy ribociclib to hormone therapy significantly improved overall survival (OS) in premenopausal patients with advanced hormone receptor-positive (HR+) breast cancer, according to results of the MONALEESA-7 Phase III clinical trial led by researchers at The University of Texas…

NRG oncology trial of metformin for non-small cell lung cancer

Initial results of NRG-LU001 indicate that, although the diabetes agent metformin was well-tolerated by patients, the agent has not clearly improved progression-free survival (PFS) or overall survival (OS) for trial participants with locally advanced non-small cell lung cancer (NSCLC). These results are based on local center reported outcomes. Trial participants will continue to be followed…

NRG trial suggests total neoadjuvant therapy for locally advanced rectal cancer is safe

Results from the first experimental arm using veliparib as part of total neoadjuvant therapy (induction chemotherapy followed by chemoradiotherapy and surgery; TNT) in patients with locally advanced rectal adenocarcinoma on the NRG Oncology Phase II clinical trial NRG-GI002 were recently presented at the American Society of Clinical Oncology (ASCO) Annual Meeting. Results were reported on…

In-situ measurement of 3D protein structure inside living eukaryotic cells

IMAGE: Target proteins are expressed inside sf9 cells, then measured using “in-cell ” NMR spectroscopy. Unique statistical analysis with the help of Bayesian inference is applied to calculate the accurate 3D structure… view more  Credit: Tokyo Metropolitan University Tokyo, Japan – Researchers from Tokyo Metropolitan University have successfully determined the high-resolution three-dimensional structure of proteins inside…