How to Talk to Someone With Alzheimer’s

“I don’t think anyone’s ever won an argument with a person with Alzheimer’s,” says Ruth Drew, who worked as a counselor in a hospital’s geriatric psychiatric ward before becoming a director with the Alzheimer’s Association, where she oversees the 24-hour 1-800 help line. Drew’s grandfather was afflicted with the degenerative brain disease. He would often…

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Objective subtle cognitive difficulties predict amyloid accumulation and neurodegeneration

Writing in the December 30, 2019 online issue of Neurology, researchers at University of California San Diego School of Medicine and Veterans Affairs San Diego Healthcare System report that accumulating amyloid — an abnormal protein linked to neurodegenerative conditions such as Alzheimer’s disease (AD) — occurred faster among persons deemed to have «objectively-defined subtle cognitive…

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A new breakthrough in developing effective antimalarial drugs

Parasites in the genus Plasmodium, which cause malaria, are transmitted to humans through bites from infected mosquitoes. The parasites manage to acclimatize to these two completely different hosts because the plasticity of their genome enables them to adapt as necessary. Scientists at the Institut Pasteur and the CNRS decided to investigate the epigenetic mechanisms behind…

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Betrayed by bile: bile acids help norovirus sneak into cells

A new study led by researchers at Baylor College of Medicine and published in the Proceedings of the National Academy of Sciences reveals that human noroviruses, the leading viral cause of foodborne illness and acute diarrhea around the world, infect cells of the small intestine by piggybacking on a normal cellular process called endocytosis that…

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Making blood on demand: How far have we come?

The reconstitution of the blood system in humans holds great therapeutic potential to treat many disorders, like blood cancers, sickle-cell anemia and others. Successful reconstitution requires the transplantation and engraftment of hematopoietic (or blood) stem cells (HSCs), which after reaching their niche, start producing all types of blood cells, including platelets, white and red blood…

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F.D.A. Failed to Ensure Safe Prescribing of Opioids, Documents Show

WASHINGTON — Newly unearthed documents show that the Food and Drug Administration failed to use its policing powers to make sure a program to curb improper prescribing of opioids was effective, researchers say. The lax oversight, they point out, occurred as the epidemic was growing and tens of thousands of people were dying from overdoses…

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Opioid Deaths Rise When Auto Plants Close, Study Shows

The last two decades have brought both a sharp decline in automaking jobs in the United States and the rise of a deadly epidemic of opioid abuse. According to a new study, the two trends may well be related. The study, published Monday in JAMA Internal Medicine, found that opioid deaths were about 85 percent…

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A Cookbook You’ll Turn to Again and Again

With its homespun snapshots, “The Corn Exchange Cookbook” is not exactly a lavish gift book, but its pages promise to become stained and dog-eared from frequent use. MJ Adams — a New York chef who worked with Tom Valenti, David Page and Edna Lewis — moved to Rapid City, S.D., in 1996 after a family…

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