Interleukin-12 electroporation may sensitize ‘cold’ melanomas to immunotherapies

Bottom Line: Combining intratumoral electroporation of interleukin-12 (IL-12) DNA (tavokinogene telseplasmid, or TAVO) with the immune checkpoint inhibitor pembrolizumab (Keytruda) led to clinical responses in patients with immunologically quiescent advanced melanoma, according to results from a phase II trial. Journal in Which the Study was Published: Clinical Cancer Research, a journal of the American Association…


A Quarantine Activity for the Wine Lover

I’ve sabered open a bottle of Champagne. But disgorging one? Yes, try this at home. Just follow the step-by-step that comes with Família Geisse’s Cave Amadeu Rústico Nature from southern Brazil. In sparkling wine parlance, disgorging refers to extracting the sediment, or lees, that accumulate as the wine develops. Traditionally it’s done by gradually turning…


Top U.K. Scientist Resigns Over Coronavirus Distancing Violation: Live Coverage

Here’s what you need to know: Caught violating his own social distancing advice, a top British scientist quits a government panel. Neil Ferguson, the epidemiologist whose frightening projections of coronavirus deaths precipitated the lockdown in Britain, resigned from the government’s scientific advisory group on Tuesday, after admitting he breached social distancing rules by illicitly meeting…


Coronavirus Live Updates: White House Says Task Force Will Wind Down

Here’s what you need to know: Video transcript Back transcript Coronavirus Task Force Will Take ‘Different Form,’ Trump Says President Trump said the White House’s coronavirus task force would be shut down and be replaced with a new group geared toward reopening the country. “I think that, as far as the task force, Mike Pence…


Paul Marks, Who Brought Sloan Kettering to Greatness, Dies at 93

His son Andrew said the cause was a combination of pulmonary fibrosis and a more recent emergence of lung cancer that was untreatable because of the fibrosis. The institution that cared for Dr. Marks at the end was very different from the one he joined in 1980 as president and chief executive, after being recruited…


Disney Takes a Coronavirus Pandemic Hit, and There’s Worse to Come

LOS ANGELES — Last year at this time, Disney was celebrating the record-breaking arrival of “Avengers: Endgame” in theaters. On Tuesday, with movie theaters closed worldwide, along with theme parks, Disney said that its quarterly profit fell more than 90 percent. And that was for a period that was only partly affected by the coronavirus.…


28 Best White Tank Tops to Shop Now

The #1 Quarantine Pick

Racerback Tank Top



Is it just me, or is this the official tank top of TikTok? Ribbed, high-necked, and slightly cropped, this $15 style goes well with sweatpants, sourdough starter, and attempting to learn the new ‘Savage Remix’ dance.

William Haddad, Crusader for Generic Drugs, Dies at 91

William Haddad, a civic evangelist who helped streamline the sale of cheaper generic drugs to American consumers and pare the price of AIDS treatment globally to a dollar a day, died on April 30 at his home in Poughquag, N.Y., in the Hudson Valley. He was 91. His daughter Lulie Haddad said the cause was…


Working From Home Has Benefits Some Don’t Want to Lose

For Jeff Anderson, 61, working from home during the coronavirus pandemic has been a respite from office politics and the chatter around the copy machine. But as the push to reopen the country’s economy intensifies, so do feelings of dread at the idea of returning to the office, said Mr. Anderson, a self-described introvert and…