Like mountaineers, nerves need expert guidance to find their way

IMAGE: Left: Motor neurons (green) exit the spinal cord (red) and enter the periphery of the body to connect with muscles. Right: Motor neurons (white arrow) without the guidance of p190… view more  Credit: Salk Institute LA JOLLA—(March 22, 2019) Similar to the dozens of Sherpas that guide hikers up treacherous Himalayan mountains to reach a…

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Squishing blood stem cells could facilitate harvest for transplants

IMAGE: How deformable cells are, and thus how stiff or squishy they are, plays an important role in retaining blood-forming stem cells in their marrow niches and thus preserving their long-term… view more  Credit: From Ni et al Cell Stem Cell (2019) Scientists at Winship Cancer Institute of Emory University, Children’s Healthcare of Atlanta and Georgia…

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When neurons are out of shape, antidepressants may not work

IMAGE: These are human serotonergic neuron projections (red) and cell bodies (green). view more  Credit: Salk Institute LA JOLLA—(March 22, 2019) Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed medication for major depressive disorder (MDD), yet scientists still do not understand why the treatment does not work in nearly thirty percent of patients with…

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4D-printed materials can be stiff as wood or soft as sponge

VIDEO: This video shows how 4D-printed smart materials can morph from stiff to soft and also change shape. view more  Credit: Chen Yang/Rutgers University-New Brunswick. Imagine smart materials that can morph from being stiff as wood to as soft as a sponge — and also change shape. Rutgers University-New Brunswick engineers have created flexible, lightweight materials…

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UTSW researchers identify new mechanism to reduce inflammation

IMAGE: Dr. Zixu Liu view more  Credit: UT Southwestern DALLAS — March 21, 2019 — UT Southwestern researchers have identified two proteins that act as gatekeepers to dampen a potentially life-threatening immune response to chronic infection. The proteins — the transcription factors SIX1 and SIX2 — activate cellular pathways required for fetal development and later switch…

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Sleep problems, Alzheimer’s disease are linked, but which comes first?

Rockville, Md. (March 22, 2019)—A new article explores the pathophysiological factors that link sleep disturbances and Alzheimer’s disease. Better understanding of this connection may lead to potential diagnostics and therapeutics for Alzheimer’s disease and other neurodegenerative diseases and dementia. The article is published ahead of print in the Journal of Neurophysiology (JNP). Alzheimer’s research has…

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Genetesis CardioFlux™ platform receives FDA 510(k) clearance

IMAGE: Patient, monitored by nurse, in a Genetesis Cardioflux™ scanner. view more  (Mason, OH March 22, 2019 8 am) Genetesis, a medical technology company focused on using biomagnetic imaging to enable rapid, noninvasive and accurate chest pain triage, has received FDA 510(k) clearance for its cardiac imaging platform. The platform pairs the CardioFlux™ Magnetocardiograph with the…

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Study reveals impact of plain cigarette packaging warnings

IMAGE: Dr Crawford Moodie view more  Credit: University of Stirling Health warnings on plain-packaged cigarettes have more of an impact on smokers than those on branded packs, according to new research from the University of Stirling. In one of the first studies to explore how smokers responded to standardised (plain) packaging, experts at the Institute of…

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Generic weight-loss drug may be safe and effective for long-term treatment

WINSTON-SALEM, N.C. — March 22, 2019 — An inexpensive weight-loss drug approved 60 years ago for only short-term use also may be safe and effective for longer-term treatment, according to a study conducted by researchers at Wake Forest Baptist Health and the Patient Outcomes Research to Advance Learning (PORTAL) network. The study is published in…

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New computational tool could change how we study pathogens

IMAGE: The FSU researchers’ new model allows for increased variation in simulations designed to identify the origins of genetic differences. The graph shows the many different environments that can change the… view more  Credit: Beerli TALLAHASSEE, Fla. — A sophisticated new analysis tool developed by Florida State University scientists may signal a new era in the…

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