30-year study identifies need of disease-modifying therapies for maple syrup urine disease

STRASBURG, PA- A new study analyzes 30 years of patient data and details the clinical course of 184 individuals with genetically diverse forms of Maple Syrup Urine Disease (MSUD), which is among the most volatile and dangerous inherited metabolic disorders. Researchers collected data on survival, hospitalization rates, metabolic crises, liver transplantation, and cognitive outcome. This…

Details

Discovery sheds new light on how cells move

When we cut our skin, groups of cells rush en masse to the site to heal the wound. But the complicated mechanics of this collective cell movement — which are facilitated by rearrangements between each cell and its neighbors — have made it challenging for researchers to decipher what’s actually driving it. «If we can…

Details

The ‘place’ of emotions

The entire set of our emotions is topographically represented in a small region of the brain, a 3 centimeters area of the cortex, report scientists in a study conducted at the IMT School for Advanced Studies Lucca, Italy. The discovery of this «map» of emotions comes from a work conducted by the Molecular Mind Laboratory…

Details

Size matters! The neuroanatomy of trigeminal neuralgia´s treatment response

London, UK: A new study published in the journal Cephalalgia, the official journal of the International Headache Society, shows unprecedented data regarding the neuroanatomical influence on the treatment response of patients with trigeminal neuralgia. The study, entitled «Hippocampal and trigeminal nerve volume predict outcome of surgical treatment for trigeminal neuralgia», was conducted by Dr. Tejas…

Details

Opioid dependence found to permanently change brains of rats

Approximately one-quarter of patients who are prescribed opioids for chronic pain misuse them, with five to 10 percent developing an opioid use disorder or addiction. In a new study, published Jan. 14, 2020 in PNAS, researchers at University of California San Diego School of Medicine found that opioid dependence produced permanent changes in the brains…

Details

‘Jumping genes’ help stabilize DNA folding patterns

«Jumping genes» — bits of DNA that can move from one spot in the genome to another — are well-known for increasing genetic diversity over the long course of evolution. Now, new research at Washington University School of Medicine in St. Louis indicates that such genes, also called transposable elements, play another, more surprising role:…

Details

Can lithium halt progression of Alzheimer’s disease?

There remains a controversy in scientific circles today regarding the value of lithium therapy in treating Alzheimer’s disease. Much of this stems from the fact that because the information gathered to date has been obtained using a multitude of differential approaches, conditions, formulations, timing and dosages of treatment, results are difficult to compare. In addition,…

Details

Coronavirus Is Spreading, but W.H.O. Says It’s Not a Global Emergency

The World Health Organization on Thursday decided not to declare the Wuhan coronavirus outbreak a global emergency, despite the spread of the dangerous respiratory infection from China to at least five other countries. Although the disease has reached beyond China, the number of cases in other countries is still relatively small, and the disease does…

Details