Wayne State University team developing new treatments for Barth syndrome

DETROIT — Barth syndrome (BTHS) is a rare and life-threatening, X-linked genetic disorder that primarily affects males and is passed from mother to son; women who are carriers do not show symptoms of the disorder. Fifty percent of children born to a mother who is a carrier will inherit the defective gene, and all daughters…

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New CRISPR-based tool can probe and control several genetic circuits at once

Every cell in our body has a computer-like control system that sends biological signals through thousands of circuits to monitor the cell’s needs and regulate its responses. But when diseases such as cancer arise, these regulatory circuits often go awry, resulting in unnatural signals and responses. The ability to accurately detect these abnormal disease signals…

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Bile duct cancer treatment potential boost from tailored medication — study

Treatment of patients suffering from bile duct cancer could be improved by tailoring medication to the levels of a key protein in people with the disease, according to new research. Cholangiocarcinoma (CCA) is a deadly disease with few treatments, but researchers in the UK and Thailand have discovered that the PRH/HHEX protein is a key…

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As Virus Tightens Grip on China, the Art World Feels the Squeeze

A single Chinese billionaire, an investor and former taxi driver named Liu Yiqian, has spent at least $200 million on art in recent years, including $170 million for a Modigliani nude in 2015. With China as the second-largest market for the global movie industry, approval or rejection by the government in Beijing can make or…

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How the Coronavirus Numbers Changed So Sharply

The number of cases and deaths in the coronavirus epidemic in China jumped sharply on Thursday as the authorities there changed how they keep track of the disease, and not, primarily, because of any change in the shape of the outbreak. There is still a lot of uncertainty about the true numbers — as with…

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Coronavirus Live Updates: China Is Tracking Travelers From Hubei

Here’s what you need to know: ImageChina is using people’s cellphones to determine if they have been to the province at epicenter of the outbreak.Credit…Noel Celis/Agence France-Presse — Getty Images Text this number to tell the Chinese authorities everywhere you’ve been recently. To combat the spread of the coronavirus, Chinese officials are using a combination…

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A Timeline of the Coronavirus

The coronavirus, which surfaced in a Chinese seafood and poultry market late last year, has spread to 24 countries, killing more than 1,000 and sickening tens of thousands of people in a matter of weeks. The World Health Organization has declared the situation a global health emergency. Here’s a timeline of what we know so…

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Sooner or Later, Zoe Kravitz Was Going to Be a Star

One afternoon in January, Zoe Kravitz was sitting in a sushi restaurant on the second floor of a Los Angeles strip mall, but her thoughts were 3,000 miles and 10 or so years away. Specifically she was thinking about her weed guy. He’d come around with product concealed in a guitar case. “He would only…

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Love Letters From World War II Reveal Promises Made and Broken

They met in Boston around Christmas in 1943, sang and played guitar at her house and shared a kiss he said he would never forget. By 1944, Leslie L. Upcraft, an Englishman, was aboard the H.M.S. Cubitt, serving the British Royal Navy while his girlfriend, Barbara Russo, a high schooler who dreamed of becoming a…

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