Too much of a good thing may lead to too much of a liver as well

All life is challenged by oxidants — reactive molecules or compounds that remove electrons from other molecules — often with adverse effect, commonly referred to as oxidative stress. Consequently, all organisms have evolved specialized antioxidant defenses. In humans and other multicellular animals, that defense depends upon a protein called NRF2 and its inhibitor, KEAP1. In…

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‘CRISPR: A Screener’s Guide’ headlines the March edition of SLAS Discovery

Oak Brook, IL — The March edition of SLAS Discovery features the cover article, «CRISPR: A Screener’s Guide,» by Carlos le Sage, Ph.D., Steffen Lawo, Ph.D., and Benedict C.S. Cross, Ph.D., (Horizon Discovery, United Kingdom). In their review, the authors discuss how CRISPR-Cas9 systems are being used widely throughout the drug discovery process and the…

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Coronavirus Live Updates: South Korea Raises Threat Alert Level

Here’s what you need to know: ImageSpraying disinfectant on Sunday at a market in Daegu, the southeastern city where many of South Korea’s coronavirus infections have been confirmed.Credit…Yonhap, via Agence France-Presse — Getty Images South Korea’s leader urges an ‘all-out, concerted response.’ President Moon Jae-in on Sunday put South Korea on the highest possible alert…

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B. Smith, Model Turned Restaurateur and Lifestyle Guru, Dies at 70

Barbara Smith, a fashion model who created a business empire by catering to the tastes of aspiring black professionals with her restaurants, television shows, bedding and furniture collections and books on entertaining, died on Saturday at her home on Long Island. She was 70. The cause was early-onset Alzheimer’s disease, her family said. Ms. Smith…

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Religious Groups in China Step Into the Coronavirus Crisis

Earlier this month, the hard-hit town of Caohe, near the center of the coronavirus outbreak in central China, received an unexpected gift: a large donation from a Taoist nunnery 550 miles away. Another Taoist temple, this one in Caohe itself, contributed tens of thousands of dollars worth of medical equipment to help those sickened by…

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Raf Simons Joins Prada as Co-Creative Director

In an unexpected move, Prada named Raf Simons as co-creative director joining Miuccia Prada. The powerhouse duo will share «equal responsibilities for creative input and decision-making.» The decision was announced on Sunday at a surprise press conference held on the last day of Milan Fashion Week. Prada joined her family’s namesake label in 1978, premiered…

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The Techlash Comes to Milan. So Does the Coronavirus Fear.

MILAN — The last days of Milan Fashion Week took place as cases of the coronavirus crept closer and news reports came that at least two people had died in nearby cities. Though there were temperature checks at the airport — a uniformed man with an electronic thermometer greeted people disembarking from London — apparently…

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Raf Simons Becomes Co-Creative Director at Prada

MILAN — In a move that could reshape the fashion world, Miuccia Prada and Patrizio Bertelli, the creative director and chief executive of the Prada Group, the thinking woman’s brand and one of the gravitational poles of the Italian industry, announced on Sunday that they were appointing the Belgian designer Raf Simons as co-creative director…

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Kanye, Out West

CODY, Wyo. — It’s surprising that a global celebrity who frequently self-identifies as the greatest artist living or dead has become an everyday presence in a tightly connected town of about 10,000 people. It’s more surprising just how much the town’s leaders want him to stay. There Kanye West is at the McDonald’s, the Best…

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