Tumor microenvironment analyzed to increase effectiveness of preclinical trials

IMAGE: Analysis of self-organization of MSCs, Hela, and PBMCs after 72 h of co-culture. Arrows indicate fused cells. (A) Alexa Fluor 647 (MSCs), (B) PE (HeLa), (C) FITC (PBMCs), (D, D1,… view more  Credit: Kazan Federal University It was shown that co-culturing HeLa adenocarcinoma cells, peripheral blood mononuclear cells, and mesenchymal stromal cells results in changes…

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Searching for better treatments for irritated tendons

IMAGE: Healthy tendon tissue (left panel) in contrast to tendinotic tissue (right) that causes pain. Researchers found that the cellular processes leading to tendinosis begin with a lack of oxygen in… view more  Credit: Rowena McBeath, M.D., Ph.D., Thomas Jefferson University PHILADELPHIA — When tendons get irritated it can lead to a serious condition called tendinosis…

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High throughput method to produce and screen engineered antimicrobial lanthipeptides

IMAGE: Alginate microbeads containing colonies of target cells (green) and producer cells (red). Where the producer cells indeed secrete active lantibiotics, the target cells have disappeared. view more  Credit: Steven Schmitt ETH Zürich Nature has provided us with lots of antimicrobials. However, given the rapid increase of antimicrobial resistance, there is a need for the development…

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Can delayed/extended-release methylphenidate allow for once daily evening dosing in ADHD?

IMAGE: Journal of Child and Adolescent Psychopharmacology is dedicated to child and adolescent psychiatry and behavioral pediatrics, covering clinical and biological aspects of child and adolescent psychopharmacology and developmental neurobiology…. view more  Credit: Mary Ann Liebert, Inc., publishers New Rochelle, NY, April 2, 2019—A new three-part study showed that a delayed-release, extended-release form of methylphenidate could…

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A New Role for Madhur Jaffrey: Rap Grandma

The halal cart was shaking. Inside the hot tin box, the 85-year-old actress and cookbook author Madhur Jaffrey, masked in giant sunglasses and a rippling white wig, was hopping up and down and making profane gestures with both hands. It was Day Two of the video shoot for “Nani,” a rap song by Zohran Mamdani,…

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Vietnam’s Empty Forests

Despite long and tragic wars with the Japanese, the French, the Chinese and the United States during the last century, Vietnam is a treasure house. It is one of the world’s hot spots of biological diversity, according to the science research. There are 30 national parks in a country a bit larger than New Mexico,…

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Front Burner: The French Cheese Biography

In his informative book, “Fromages,” Dominique Bouchait explains French cheeses, dividing them into “families,” according to how they’re made, like cooked and uncooked or blue-veined. But what he says about the French varieties applies to cheeses from anywhere. Though Mr. Bouchait — a master cheesemaker based in southwest France — focuses on the 45 French…

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Front Burner: A Parisian Pastry Pop-Up

Cédric Grolet — the award-winning pastry chef at Le Meurice, one of Paris’s grand hotels — will take up residence at Dominique Ansel’s bakery in SoHo from Friday through Sunday. He will work with Mr. Ansel and his staff to make some of his dazzling confections mimicking fruits and nuts — lemons, strawberries and hazelnuts,…

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Front Burner: Attend the Staff Wine Lesson

There are wine classes galore in New York, but Charlie Bird restaurant in SoHo offers an insider’s approach: The tastings, intended for staff, are open to the public free of charge, once a week with a reservation. Grant Reynolds, the wine director and a partner, runs the lively program. Three wines are usually sampled and…

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Front Burner: Gravlax With a Twist

Durham’s Tracklements, in Ann Arbor, Mich., uses various cures to produce its smoked salmon and other fish. Traditionally, gravlax is salmon cured with salt and spices. Tracklements adds smoking to the process, resulting in salmon that’s mild (though rich), with a hint of smoke. Another new smoked salmon on the roster is cured with ras-el-hanout,…

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