No improvement in death rate for COVID-19 patients who received hydroxychloroquine

Boston, MA — A research team led by investigators from Brigham and Women’s Hospital has evaluated real-world evidence related to outcomes for COVID-19 patients who were treated with hydroxychloroquine or chloroquine analogues (with or without a macrolide). Investigators found no evidence that either drug regimen reduced the death rate among patients. Patients treated with hydroxychloroquine…

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‘Time is vision’ after a stroke

A person who has a stroke that causes vision loss is often told there is nothing she can do to improve or regain the vision she has lost. New research from the University of Rochester, published in the journal Brain, may offer hope to stroke patients in regaining vision. The Rochester team found that survivors…

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When developing vaccines against COVID-19, ‘fast is slow, and slow is fast’

Bypassing clinical trials for a potential SARS-CoV-2 vaccine would be «catastrophic,» says Science Advances deputy editor Douglas Green in this Editorial. Instead, it’s vital to take time to ensure any vaccine candidate’s safety and investigate potential adverse effects, he says. A vaccine able to trigger strong neutralizing antibody responses in clinical tests will still not…

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Large-scale analysis of protein arginine methylation by mass spectrometry

Methylation (namely addition of a methyl group) of arginine amino acid residues of proteins is a post-translational modification (PTM) catalyzed by a family of nine enzymes called Protein Arginine Methyl-Transferases (PRMTs). PRMTs have been gaining increasing attention in the scientific landscape due their role in several essential physiological processes and implication in various diseases, including…

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A clue as to why it’s so hard to wake up on a cold winter’s morning

EVANSTON, Ill. — Winter may be behind us, but do you remember the challenge of waking up on those cold, dark days? Temperature affects the behavior of nearly all living creatures, but there is still much to learn about the link between sensory neurons and neurons controlling the sleep-wake cycle. Northwestern University neurobiologists have uncovered…

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Introducing TVT connect

NEW YORK — May 22, 2020 — The Cardiovascular Research Foundation (CRF) has announced that TVT Connect, the Structural Heart Summit, will take place online June 18-28, 2020. TVT Connect features expertly developed series, late-breaking clinical science, challenging cases, industry-sponsored sessions, and connection to a community of thought leaders from across the globe. «We transformed…

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Anti-obesity medications mitigate weight regain in RYGB surgery patients

SILVER SPRING, Md.—Researchers have discovered that anti-obesity medications such as phentermine and topiramate, used individually or in combination, can significantly reduce weight regain in patients after Roux-en-Y gastric bypass surgery, according to a retrospective study published online in Obesity, the flagship journal of The Obesity Society. «Our study provides evidence that medications can help, especially…

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