The point when human embryonic stem cells irreversibly commit to becoming specialised has been identified by researchers at the Francis Crick Institute. Our biological history can be traced back to a small group of cells called embryonic stem cells, which through cell division, give rise to cells that specialise to perform a specific role in…
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Two new species of viruses have been identified in blood samples taken from patients in Brazil’s northern region who had similar symptoms to those of dengue or Zika, such as high fever, severe headache, rash and red skin spots. One belongs to the genus Ambidensovirus and was found in a sample collected in the state…
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Clinical laboratory physicians and scientists at UC San Diego Health have launched a pair of serological tests that will look for novel coronavirus antibodies — evidence in persons tested that they have previously been infected by SARS-CoV-2, the viral cause of COVID-19, even if they never experienced tell-tale symptoms. The effort will be overseen by…
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Kylene Kehn-Hall, Associate Professor/Associate Director, School of Systems Biology, National Center for Biodefense and Infectious Diseases, is working to rapidly test and deploy a universal virus enrichment tool that can be used to enhance the detection of SARS-CoV-2 (COVID-19) for any type of diagnostic assay under development, thereby reducing false negatives and the risk of…
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Engineering researchers developed a next-generation miniature lab device that uses magnetic nano-beads to isolate minute bacterial particles that cause diseases. Using this new technology improves how clinicians isolate drug-resistant strains of bacterial infections and difficult-to-detect micro-particles such as those making up Ebola and coronaviruses. Ke Du and Blanca Lapizco-Encinas, both faculty-researchers in Rochester Institute of…
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Abnormal levels of stress hormones such as adrenaline and cortisol are linked to a variety of mental health disorders, including depression and posttraumatic stress disorder (PTSD). MIT researchers have now devised a way to remotely control the release of these hormones from the adrenal gland, using magnetic nanoparticles. This approach could help scientists to learn…
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After comparing how infections from SARS-CoV-2 (which causes COVID-19) and two other human coronaviruses develop in cynomolgus macaques, researchers report that SARS-CoV-2 gives the animals a mild COVID-19-like disease. The results — based on a combination of experimental and historical infection data — suggest these animals are a promising model for testing COVID-19 therapeutics. Treatments…
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As the COVID-19 pandemic continues, a major unanswered question is how SARS-CoV-2 will persist in the human population after its initial pandemic stage. A new modeling study suggests that the total incidence of the virus through 2025 will depend crucially on the duration of human immunity — of which scientists know little now. Longitudinal serological…
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A recently developed system for switching on the activity of genes could improve treatments for a broad range of neurological diseases. Esteban Engel, a researcher in viral neuroengineering in the Princeton Neuroscience Institute, and his team have developed new gene promoters — which act like switches to turn on gene expression — that promise to…
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In a New England Journal of Medicine «Perspective» published today, Wafaa El-Sadr, MD, MPH, global director of ICAP at Columbia University Mailman School of Public Health, and Jessica Justman, MD, ICAP’s senior technical director, and associate professor of epidemiology, urge a coordinated global effort in the face of the COVID-19 pandemic, with «countries around the…
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