An Alzheimer’s Drug Trial Fails: ‘We Don’t Have Anything Now’

The study aimed to show that Alzheimer’s disease could be stopped if treatment began before symptoms emerged. The participants were the best candidates that scientists could find: still healthy, but with a rare genetic mutation that guaranteed they would develop dementia. For five years, on average, the volunteers received monthly infusions or injections of one…

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Seeing the Oscar Challenge to Fashion Week and Raising It One

New York Fashion Week dribbled into existence just after President Trump’s impeachment acquittal victory lap, and in the shadow of the Bernie-Buttigieg squabbles over Iowa. Not to mention the Oscars. It was not the optimum moment for the first fashion week of the third decade of the new century to start. It was too easy…

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Your Foam Coffee Cup Is Fighting for Its Life

MASON, Mich. — The Dart Container Corporation, by some measures, is an American success story. The family-owned business was co-founded in Michigan by a World War II veteran with a triple major in mathematics, engineering and metallurgy, and it developed products that, in no small way, helped fuel the modern economy. Dart makes, by the…

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Canned Artichokes Deserve Your Respect

I love to do things in the kitchen that take up a lot of time, tasks that feel special and maybe a little fussy. Things like soaking precious beans overnight, shucking pounds of fresh peas from their pod and gingerly trimming thorny raw artichokes to steam and eat with clarified butter. I also love convenience,…

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Lessons That Go Beyond the Coronavirus Outbreak

News of coronavirus infections is causing many people to panic. It’s unclear how widespread or deadly this illness is going to be, but for once, instead of telling you not to worry, I’m going to suggest riding that wave. Channel that fear into useful action — and find the lessons that go beyond this outbreak.…

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Actual Decadence!

Good morning. Valentine’s Day is Friday, a Hallmark holiday for some, with cards and chocolates and roses of questionable provenance, dinners in candlelight, public displays of affection set to stun. If you’re celebrating, I hope you have your reservations made or your caviar order in. You don’t want to be scrambling around on Thursday or…

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A Job Overseas, but Stranded by Coronavirus Travel Bans

HONG KONG — Jade Doringo arrived at Manila’s international airport more than five hours ahead of her scheduled departure to Hong Kong, where she worked as a software engineer. But instead of getting on her flight, she was asked to surrender her boarding pass. That morning, on Feb. 2, President Rodrigo Duterte of the Philippines…

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The Oscars Red Carpet: Let’s Give Them Something to Talk About

Old Hollywood — and the way it is represented by the Academy of Motion Picture Arts and Sciences and its award nominations — has been under the microscope for a while now, whether because of #OscarsSoWhite or #MeToo or the lack of recognition of female directors (and the lack of recognition of Jennifer Lopez in…

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The Next Crop of It-Bags Carried at NYFW

It’s no surprise that one great bag can be the star of any outfit. It can make or break a look. Thankfully, New York Fashion Week fall-winter 2020 is coming through with the latest hits, where designers are embracing all of the patterns, textures, and shapes we’re dying to test out next season. At Longchamp,…

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On Broadway, the Art of Adornment

Given the scarcity of space in Manhattan, New Yorkers often imagine vast possibilities for places that others would consider suitable for a walk-in closet. That was what happened two years ago, when Karen Davidov found a one-room office on the eighth floor at 1239 Broadway, downstairs from the studio where she works with her architect…

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