A more accurate method to diagnose cancer subtypes

IMAGE: Garvan researchers have developed a method for detecting the products of ‘fusion’ genes in cancer cells more accurately than current clinical methods. view more  Credit: Garvan Institute Developed by researchers at the Garvan Institute of Medical Research, this potential diagnostic method screens a cancer sample for ‘fusion genes’, estimated to be linked to one in…

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On the keto diet? Ditch the cheat day, says UBC study

IMAGE: UBC researchers are arguing that those on a keto diet should pause when considering a ‘cheat day.’ view more  Credit: Nathan Skolski, UBC Okanagan The often embraced ‘cheat day’ is a common theme in many diets and the popular ketogenic diet is no exception. But new research from UBC’s Okanagan campus says that just one…

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Helping infants survive brain cancer

IMAGE: Robert Wechsler-Reya, Ph.D., senior author of the paper, professor and director of the Tumor Initiation and Maintenance Program at Sanford Burnham Prebys, and program director of the Joseph Clayes III… view more  Credit: Sanford Burnham Prebys LA JOLLA, CALIF. — March 27, 2019 — Choroid plexus carcinoma (CPC) is a particularly challenging type of brain…

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Common medication used in pregnancy may lead to obesity in children

Metformin is often used during pregnancy where the mother is suffering from polycystic ovary syndrome (PCOS). A study from the Norwegian University of Science and Technology (NTNU) has recently shown that this results in fewer miscarriages and premature births. But a companion Norwegian study shows that children who are exposed to metformin in the womb…

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Human protein produced in CHO-cells can save donor blood

Alpha-1-antitrypsin is a protein produced by the liver. The protein gets secreted to the blood stream, where it circulates the body to protect the lungs. However, some people are born with genetic disorders that hinders production of this protein. These patients can suffer from decreased lung function, liver diseases and shortness of breath. In the…

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New medication gives mice bigger muscles

It is common knowledge that as people grow older they lose a large part of their muscle mass — and neither are their bones what they once were. Researchers from Aarhus University, Denmark, working together with researchers at Erasmus Medical Center in Rotterdam have now studied a new group of medication which could prove beneficial…

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How nerve cells control misfolded proteins

IMAGE: Dr. Verian Bader and Ana Sánchez Vicente are members of the research team headed by Professor Konstanze Winklhofer (in the background) which has revealed a new role of the protein… view more  Credit: RUB, Marquard Researchers have identified a protein complex that marks misfolded proteins, stops them from interacting with other proteins in the cell…

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Two new Emmy Noether Independent Junior Research Groups at Charité

IMAGE: The neurons of the enteric nervous system — what role do they play in the regulation of the body’s immune response? view more  Credit: Photo: Klose/Charité How can we further improve deep brain stimulation and its use in the treatment of neurological disorders? How does the nervous system regulate both protective and chronic immune responses?…

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Tumor-promoting enzymes USP25 and USP28: Substantial differences identified

IMAGE: Structures of the catalytic domains of USP28 and USP25: USP28 is a constitutively active dimer and can bind and process ubiquitin (orange) at any time. In contrast, USP25 is a… view more  Credit: Picture: Rudolf Virchow Center of experimental biomedicine / University of Wuerzburg The permanent interplay of protein production and degradation is a major…

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Glowing tumors show scientists where cancer drugs are working

IMAGE: Radiolabeled protein lights up tumor implanted in the arm of a mouse under a PET scan. The researchers hope to use scans like this one to to calculate in real… view more  Credit: Sridhar Nimmagadda Experimenting with mice, Johns Hopkins researchers report they have successfully used positron emission tomography (PET) scans to calculate in real…

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