Immediate dialysis no better than wait-until-necessary approach, researchers find

In the largest international study of its kind, researchers at the University of Alberta and Toronto’s St. Michael’s Hospital found that an accelerated renal-replacement therapy strategy did not reduce mortality after three months, compared to a standard strategy for critically ill patients with acute kidney injury. The Standard vs. Accelerated Initiation of Renal Replacement Therapy…

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Patients with substance use disorder discriminated against by post-acute care facilities

Boston — A new study shows that 29 percent of private post-acute care facilities in Massachusetts explicitly discriminated against hospitalized individuals with opioid use disorder, rejecting their referral for admission. Led by researchers at Boston Medical Center’s (BMC’s) Grayken Center for Addiction, the study showed that 15 percent of the rejections among patients with substance…

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Combating drug resistance in age-related macular degeneration

An international team of researchers led by Baylor College of Medicine and Houston Methodist has discovered a strategy that can potentially address a major challenge to the current treatment for choroidal neovascularization (CNV), an aggressive form of age-related macular degeneration, the leading cause of irreversible blindness in the elderly. Anti-vascular endothelial growth factor (anti-VEGF)…

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Chest x-rays show more severe COVID-19 in non-white patients

OAK BROOK, Ill. (July 16, 2020) — Racial/ethnic minority patients admitted to the hospital with COVID-19 infection are more likely to have more severe disease on chest X-rays than white/non-Hispanic patients, increasing the likelihood of adverse outcomes, such as intubation or death, according to a study published in the journal Radiology. Emerging data show that…

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Dangerous blood clots form in leg arteries of COVID-19 patients

OAK BROOK, Ill. (July 16, 2020) — COVID-19 is associated with life-threatening blood clots in the arteries of the legs, according to a study published in Radiology. Researchers said COVID-19 patients with symptoms of inadequate blood supply to the lower extremities tend to have larger clots and a significantly higher rate of amputation and death…

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Cancer cells in inhospitable brain fluids hijack iron to survive

In order to survive within the remote and harsh anatomical microenvironments of the central nervous system, the disseminated cancer cells that cause rare yet deadly leptomeningeal metastases (LM) hijack crucial iron micronutrients from native macrophages, researchers report. The work highlights the remarkable plasticity of tumor cells and reveals potential new avenues for treating these particularly…

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Aging-associated inflammation may worsen COVID-19 outcomes in older individuals

The increased severity and mortality of SARS-CoV-2 infections in older individuals may be related to inflammageing — an age-associated phenomenon of increased general inflammation. In this Perspective, Arne Akbar and Derek Gilroy discuss this possibility as well as strategies to mitigate related effects. Inflammageing is thought to be caused, at least partially, by deterioration of…

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What to Do When Most Days Feel Like Wednesdays

Welcome. How are you? Wednesdays were a bear even before the pandemic came to town and made most days feel like Wednesdays. Now Wednesdays are like Wednesdays squared, like Nebraska on a cross-country drive, 456 miles from Omaha in the East all the way to the Wyoming line. They’re a long way from a weekend…

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