A simple screening process may enhance monoclonal antibody-based drug development

By screening potential monoclonal antibody (mAb)-based drugs solely based on a measure of their colloidal stability, scientists may be able to weed out mAbs that do not respond efficiently in solution early in the drug discovery process, according to a new study. This finding could enable researchers to overcome a major hurdle to drug development…

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Adjustable lordotic expandable vs static lateral lumbar interbody fusion devices

The background of this research is based on the use of large interbody spacers in minimally invasive (MIS) lateral lumbar interbody fusion (LLIF) that offer favorable clinical and radiographic results. The static interbody spacers are likely to cause iatrogenic endplate damage and implant subsidence due to strong impaction and too much trialing. Whereas expandable interbody…

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Insights on the gut microbiome could shape more powerful, precise treatment

Using real-world data and predictive models, investigators identify key factors that determine success of fecal microbiota transplantation Framework also provides an algorithm for designing a personalized probiotic cocktail to decolonize harmful bacteria in the gut We may not think about it often, but our gut is home to a complex ecosystem of microorganisms that…

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15 New Designer Handbags to Invest In Now

We’re on the tail-end of summer, which means the latest bag drops are happening right now. Shopping between seasons is the perfect time to find a bag that works year-round. It’s when designers like Loewe, Chanel, and Gucci release season-less styles in mixed materials, prints, and more. From silhouettes sourced directly from atelier archives to…

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We Found a Secret Everlane Sale Where Jeans, Sweaters, and Shoes are 50% Off

We’ve all been quarantining at home for—checks notes—nearly 5 months at this point. If you could use a well-deserved pick-me-up or a distraction right about now, you’re in luck. We stumbled upon a treasure trove of steeply discounted Everlane staples at Nordstrom Rack. Whether your WFH outfit rotation could use some comfy, new pieces or…

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Before The Devil Wears Prada and The Bold Type There Was Intern

Style Points is a new weekly column about how fashion intersects with the wider world. Several years ago, a stranger came up to Jill Kargman at a party to say, “Oh my God, I’m a fan.” She assumed they were talking about her Bravo series Odd Mom Out, which drew on Kargman’s experiences as an…

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The Dog Days of Quarantine

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Children May Carry Coronavirus at High Levels, Study Finds

It has been a comforting refrain in the national conversation about reopening schools: Young children are mostly spared by the coronavirus and don’t seem to spread it to others, at least not very often. But on Thursday, a study introduced an unwelcome wrinkle into this smooth narrative. Infected children have at least as much of…

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A Covid Patient Goes Home After a Rare Double Lung Transplant

The last thing that Mayra Ramirez remembers from the emergency room at Northwestern Memorial Hospital in Chicago is calling her family to say she had Covid, was about to be put on a ventilator and needed her mother to make medical decisions for her. Ms. Ramirez, 28, did not wake up for more than six…

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