Combined cediranib and olaparib presents similar activity to standard of care treatment

Results of the NRG Oncology phase III clinical trial NRG-GY004 indicated that the addition of the investigational agent cediranib to olaparib and standard platinum-based chemotherapy did not improve progression-free survival (PFS) outcomes for women with platinum-sensitive ovarian cancer;, however, activity between the treatments were similar in patients. These results were recently presented at the virtual…

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Assessing cancer diagnosis in children with birth defects

Scientific studies suggest that children with birth defects are at increased risk of cancer. However, it has not been assessed whether the type of cancer, the age at which they are diagnosed or the extent of cancer spread at the time of diagnosis, is different for children with birth defects compared to children without birth…

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About 30 Million Euros for excellent research

The German Research Foundation (DFG) has approved a new proposal for a collaborative research centre (CRC) under the leadership of the Institute for Experimental Cardiovascular Medicine (IEKM) at the University Heart Centre Freiburg · Bad Krozingen. The CRC 1425 «The heterocellular nature of cardiac lesions: Identities, interactions, implications» will be funded by the DFG with…

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Researchers develop new method to map cholesterol metabolism in brain

A team of researchers led by Swansea University have developed new technology to monitor cholesterol in brain tissue which could uncover its relation to neurodegenerative disease and pave the way for the development of new treatments. The research, published in the Proceedings of the National Academy of Sciences of the USA, shows the major locations…

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When COVID-19 meets flu season

CHICAGO — As if the COVID-19 pandemic isn’t scary enough, the flu season is not far away. How severe will the flu season be as it converges with the COVID-19 outbreak? What can we do to prepare? Dr. Benjamin Singer, a Northwestern Medicine pulmonologist who treats COVID-19 patients in the intensive care unit, outlines the…

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Key grant positions USC as leader in dental and craniofacial tissue regeneration

THE STUDIES SEEM LIKE something straight out of science fiction. There’s one focused on using stem cells to regenerate skull bone for patients with skull defects. Another aims to develop a hydrogel patch that could reduce scarring and regenerate hair follicles and sweat glands in burn victims. Another looks to create a transdermal patch that…

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Evolution of pandemic coronavirus outlines path from animals to humans

DURHAM, N.C. — A team of scientists studying the origin of SARS-CoV-2, the virus that has caused the COVID-19 pandemic, found that it was especially well-suited to jump from animals to humans by shapeshifting as it gained the ability to infect human cells. Conducting a genetic analysis, researchers from Duke University, Los Alamos National Laboratory,…

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Researchers from Syracuse University and SUNY ESF track COVID-19 in wastewater

Epidemiologist David Larsen, from Syracuse University and microbiologists Hyatt Green, from the College of Environmental Science and Forestry and Frank Middleton, from Upstate Medical University are lead members of a multi-institution research project that is expected to have global application in future efforts to track and contain Sudden Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the…

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Oesophageal surgery: Quality increases with larger case volumes

In complex surgery, is there a correlation between the volume of services provided per hospital and the quality of treatment results? This is the question addressed in eight commissions on minimum volumes that the Federal Joint Committee (G-BA) awarded to the Institute for Quality and Efficiency in Health Care (IQWiG). The IQWiG report is now…

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