Researchers pursue ‘hidden pathology’ to explain fatigue in multiple sclerosis

Up to 60 percent of patients with multiple sclerosis (MS) report that fatigue is the disease’s most debilitating symptom. And yet, fatigue remains one of MS’s mysteries — despite its prevalence and significance, the root cause of the symptom remains unclear. In a study published in Neurology Neuroimmunology & Neuroinflammation, investigators from Brigham and Women’s…

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Progress toward a treatment for Krabbe disease

In one out of 100,000 infants, a mutation in the GALC gene causes an incurable, always fatal disorder known as infantile Krabbe disease, or globoid cell leukodystrophy. Most children with the condition die before they turn 2. A parallel condition also naturally affects dogs, who typically show symptoms of the disease at six weeks old…

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McDonald’s Investigating Whether Former C.E.O. Covered Up Others’ Misconduct

McDonald’s said on Tuesday that its investigation into misconduct claims within the company now included whether its former chief executive, Steve Easterbrook, may have covered up inappropriate actions by other executives during his tenure. The company also said it was examining the actions of its human resources department. “The board will follow the facts wherever…

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Airline Job Cuts Could Pressure Congress and Trump on Stimulus

American Airlines warned employees on Tuesday that it would cut up to 19,000 workers on Oct. 1, saying that there was little sign that the pandemic-induced reluctance to travel was diminishing. The airline is looking to cut thousands of flight attendants, pilots, technicians, gate agents and other staff, it said. Including buyouts, retirements and leaves…

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How the Hollywood Fix Cornered the Influencer Paparazzi Market

Mr. Greene’s videos have become so ubiquitous on the teen internet that they’re now a meme. Hundreds of young people on TikTok have posted Hollywood Fix parody videos, and YouTubers like Emma Chamberlain have referenced the Hollywood Fix in their videos. People often parrot Mr. Greene’s signature catch phrase — “The fans wanna know!” —…

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C.D.C. Now Says People Without Covid-19 Symptoms Do Not Need Testing

The Centers for Disease Control and Prevention quietly modified its coronavirus testing guidelines this week to exclude people who do not have symptoms of Covid-19 — even if they have been recently exposed to the virus. Experts questioned the revision, pointing to the importance of identifying infections in the small window immediately before the onset…

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Can You Get a Flu Shot Now? Yes, and Doctors Say You Should

People usually don’t think about flu shots until the fall, so you might be surprised to learn that many places are already offering them. Public health officials, fearing that the confluence of Covid-19 and influenza cases could result in a “twindemic” that will further overburden hospitals and testing locations, are urging vaccination for nearly everyone.…

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Flu Season Could Make Coronavirus Testing Delays Even Worse

Come fall, the rise of influenza and other seasonal respiratory infections could exacerbate already staggering delays in coronavirus testing, making it easier for the virus to spread unnoticed, experts said. In typical years, doctors often don’t test for flu, simply assuming that patients with coughs, fevers and fatigue during the winter months are probably carrying…

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Can Love Survive This Election?

Julie Sanchez, a business operations consultant in Orcutt, Calf., recently celebrated her 15th wedding anniversary — a milestone that she wasn’t sure she would hit, given the recent strain politics has brought to her marriage. “There’s a giant elephant and a giant donkey, and they’re both in the living room,” was how Ms. Sanchez, 59,…

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