Cellular pathway of genetic heart disease similar to neurodegenerative disease

ROCHESTER, Minn. — Research on a genetic heart disease has uncovered a new and unexpected mechanism for heart failure. This landmark discovery found a correlation between the clumping of RNA-binding proteins long linked to neurodegenerative disease ? and the aggregates of protein found in the heart tissue of patients with RBM20 dilated cardiomyopathy. Dilated cardiomyopathy…

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Tau protein changes in Alzheimer’s disease correlate with dementia stage

Research into Alzheimer’s disease has long focused on understanding the role of two key proteins, beta amyloid and the tau protein. Found in tangles in patients’ brain tissue, a pathological form of the tau protein contributes to propagating the disease in the brain. In new research from their joint laboratory, Judith Steen, PhD, and Hanno…

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The Coronavirus Vaccines Will Likely Work. Making Them Fast Will Be Hard.

The promising news that not just one but two coronavirus vaccines were more than 90 percent effective in early results has buoyed hopes that an end to the pandemic is in sight. But even if the vaccines are authorized soon by federal regulators — the companies developing them have said they expect to apply soon…

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Americans Are More Willing to Take a Coronavirus Vaccine, Poll Suggests

In a sign that Americans are becoming less hesitant to take a coronavirus vaccine, a Gallup poll released on Tuesday showed that 58 percent of the adults who were surveyed were willing to be vaccinated, up from 50 percent in September. The survey was conducted between Oct. 19 and Nov. 1, as coronavirus cases were…

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7 Podcasts From Familiar Faces

As the podcast boom has snowballed over the past few years, so has the number of star vehicles in audio form. Once seen as a hobby, or at best a side hustle, podcasts now provide an opportunity for stars to connect directly with their audience. And ever since the pandemic brought film, TV and live…

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Diana’s Dresses on The Crown, a Fashion Horror

And so, once again, to Princess Diana. Like Jacqueline Kennedy Onassis, she has become a sort of cultural Rosetta Stone we return to over and over, seeking to discover answers to our own choices in her limpid blue stare and cacophonous, attention-grabbing wardrobe. This time around the re-examination comes courtesy of “The Crown,” Season 4,…

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Tiny Love Stories: ‘It Soothes Me to Know Someone So Gentle’

Magic in Manila At 5, I believed that my father could perform magic. In Manila’s moist heat, he drove in stop-and-go traffic with five screaming children and a broken AC. If we were very quiet, he said, he would use his powers to make the billboard flip screens. We quieted and he chanted an incantation,…

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Immunity to the Coronavirus May Last Years, New Data Hint

How long might immunity to the coronavirus last? Years, maybe even decades, according to a new study — the most hopeful answer yet to a question that has shadowed plans for widespread vaccination. Eight months after infection, most people who have recovered still have enough immune cells to fend off the virus and prevent illness,…

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This Is Not Your Average Pumpkin Soup

A bowl of soup may not be a staple on every Thanksgiving table, but as Americans plan for holiday gatherings that are smaller than usual, or even virtual, serving a rich, comforting soup as a first course is an easy way to make sure the meal still feels special and celebratory. In this recipe for…

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