CDK inhibitors may improve immune therapy effectiveness for recurrent breast cancer

Recurrent, metastatic breast cancer resists treatment and is usually fatal. These tumors often have low numbers of immune cells in them, which renders immune therapies less effective for the disease. This preclinical study suggests that drugs called CDK4 and CDK6 inhibitors may make immune-cell therapies an effective option for treating recurrent ER-positive metastatic breast cancer.…

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For twins, gesture and speech go hand-in-hand in language development

ATLANTA–Gestures–such as pointing or waving–go hand in hand with a child’s first words, and twins lag behind single children in producing and using those gestures, two studies from Georgia State University psychology researchers show. Twins produce fewer gestures and gesture to fewer objects than other children, said principal researcher Seyda Ozcaliskan, an associate professor in…

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NIH awards Marshall University professor $1.8 million for nicotine addiction research

HUNTINGTON, W.Va. – Brandon J. Henderson, Ph.D., an assistant professor of biomedical sciences at the Marshall University Joan C. Edwards School of Medicine, has been awarded a Research Project Grant (R01), one of the most competitive grants issued by the National Institutes of Health (NIH). Henderson was awarded the $1.86 million five-year grant (R01DA050717) from…

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Controlling cholesterol in microglia alleviates chronic pain, opioid-free

Chemotherapy can induce a painful peripheral neuropathy (CIPN), a chronic condition and common adverse effect for cancer patients undergoing treatment. Researchers at University of California San Diego School of Medicine, with colleagues elsewhere, have used a mouse model to demonstrate the pivotal role of cholesterol in CIPN, and proposed a novel therapeutic approach to reverse…

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