Towards a blood test for early-stage liver disease

— Scientists looked for early detection method for non-alcoholic fatty liver disease (NAFLD) — Plasma proteins of NAFLD patients were analyzed by mass spectrometry — Six proteins were detected in the blood associated with the early stages of NAFLD — Protein PIGR identified as candidate biomarker for liver damage tests One in four people in…

Details

EMA qualification opinion on cellular therapy module of the EBMT Registry

The European Society for Blood and Marrow Transplantation (EBMT) registry has been qualified by EMA as a suitable platform for the collection of data for post-authorisation safety surveillance studies. The registry is now considered suitable to perform pharmacoepidemiological studies for regulatory purposes, concerning Chimeric Antigen Receptor (CAR) T-cell therapy used in the treatment of haematological…

Details

Considerably reduced toxicant levels in heated tobacco prototype compared to cigarettes

Bristol, February 28th 2019 — New research* suggests that toxicants of notable public health interest are substantially reduced in the aerosol from our heated tobacco product (HTP) prototype, compared to smoke from a standard reference cigarette. HTPs generate a nicotine-containing aerosol with a tobacco taste through the heating of tobacco via an electrical device. The…

Details

Embryos’ signaling proteins go with the flow

IMAGE: Rice University graduate student Joseph Massey sets up an experiment to study the WNT signaling pathway in developing cell lines. The pathway plays a central role in cell differentiation as… view more  Credit: Jeff Fitlow/Rice University HOUSTON — (March 1, 2019) — How cells in developing embryos communicate depends a great deal on context, according…

Details

Bioluminescence sensors make new approaches to drug discovery possible

Canadian researchers, working in partnership with Brazilian colleagues, have developed 13 bioluminescence sensors for use in testing the effectiveness of new medical drugs in the laboratory. The study, published in the journal Science Signaling, paves the way for new drugs to be tested and characterized. The biosensors are based on the action of G protein-coupled…

Details

How hair dye works (video)

IMAGE: Whether you need a disguise to run from the law or are just trying to emulate *NSYNC-era frosted tips, you may need some chemical assistance to put the hue in… view more  Credit: The American Chemical Society WASHINGTON, March 1, 2019 — Whether you need a disguise to run from the law or are just…

Details

Tracking firefighters in burning buildings

IMAGE: McMaster University researchers, working with colleagues from other institutions led the development of a self-powered, fireproof sensor to track the movements of firefighters and others who work beyond the line… view more  Credit: McMaster University HAMILTON, March 1, 2019 — McMaster researchers, working with partners at other universities, have created a motion-powered, fireproof sensor that…

Details

High-fat diet and age alter microflora and cause inflammation in heart failure

IMAGE: This is Ganesh Halade. view more  Credit: UAB BIRMINGHAM, Ala. — Growing older and a high-fat diet enriched with omega 6 fatty acids are major contributors to health risks ranging from diabetes to heart failure. How these two factors regulate the immune response is not well-understood. Ganesh Halade, Ph.D., and colleagues at the University of…

Details