The Loneliness of Frontotemporal Dementia

At 66, Bob Karger was losing language. It was not the tip-of-the-tongue feeling that melts when you recall a sought-after word. He had lost the connection between sounds and meaning — the way ba-na-na recalls a soft, yellow fruit or ea-gle calls to mind a large bird of prey. In a recent conversation, he had…

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Trump Administration Sues Gilead, Maker of H.I.V.-Prevention Drugs

The Trump administration on Wednesday sued Gilead Sciences, a pharmaceutical company that sells H.I.V.-prevention drugs that can cost patients up to $20,000 a year, accusing the company of earning billions from research funded by taxpayers without paying taxpayers back. The government said the company infringed upon patents owned by the Department of Health and Human…

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The Met’s Next Big Fashion Show Revealed

When Andrew Bolton, the curator in charge of the Costume Institute of the Metropolitan Museum of Art, had to come up with a blockbuster in celebration of the Met’s 150th anniversary in 2020 — a blockbuster to follow the blockbusters that were about Catholicism and camp; a blockbuster to do what blockbusters do, which is…

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The Party Girl, Till the End

“Is this for my obit?” The Instagram direct message came in reply to a reporter’s query to Nina Griscom. It was meant to be humorous but also not. Whip smart, potty mouthed and uncommonly direct, Ms. Griscom, 65, is a celebrated “It” girl from an earlier era. The decade in question was the 1980s, a…

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How to Feel Nothing Now, in Order to Feel More Later

SAN FRANCISCO — Everything was going really well for the men of Tennessee Street. Women wanted to talk to them, investors wanted to invest, their new site got traffic, phones were buzzing, their Magic: The Gathering cards were appreciating. This all was exactly the problem. They tried to tamp the pleasure. They would not eat…

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The way of making memories

How does the brain translate information from the outside world into something we remember? An international team of researchers working in the Human Brain Project have zoomed in on the neuronal circuits in the striatum, a brain structure involved in memory, behavior and reward learning. The findings, published in the PLOS Computational Biology Journal, increase…

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Vitamin D and Omega 3 supplements do not reduce risk of systemic inflammation

Vitamin D and marine omega-3 fatty acids — also known as fish oil — are purported to have many health benefits, including reducing systemic inflammation. Signals of systemic inflammation are tied to diseases of aging and obesity, including cardiovascular disease, heart failure, osteoporosis, diabetes mellitus, some cancers, and neurodegenerative diseases such as Alzheimer’s disease. While…

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Personalized gene networks enhance study of disease

Researchers at Penn State College of Medicine have developed a new method to model how genes interact with each other — and it may someday contribute to the development of personalized treatments for patients. According to the researchers, the new model is able to construct personalized networks for an individual patient that can show…

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Study provides insights on the effects of cannabidiol on severe form of epilepsy

Results from a study published in the British Journal of Clinical Pharmacology may help explain why cannabidiol—a chemical component of marijuana with no psychoactive properties—reduces the frequency of seizures in patients with a severe form of epilepsy. The effect may be explained by a drug-drug interaction between cannabidiol and the anti-seizure medication clobazam. The form…

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Modified CRISPR gene editing tool could improve therapies for HIV, sickle cell disease

DUARTE, Calif. — City of Hope researchers may have found a way to sharpen the fastest, cheapest and most accurate gene editing technique, CRISPR-Cas9, so that it can more successfully cut out undesirable genetic information. This improved cutting ability could one day fast-track potential therapies for HIV, sickle cell disease and, potentially, other immune conditions.…

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